DOK2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDOK2, p56DOK, p56dok-2, docking protein 2
External IDsOMIM: 604997 MGI: 1332623 HomoloGene: 2957 GeneCards: DOK2
Orthologs
SpeciesHumanMouse
Entrez

9046

13449

Ensembl

ENSG00000147443

ENSMUSG00000022102

UniProt

O60496

O70469

RefSeq (mRNA)

NM_003974
NM_201349
NM_001317800
NM_001401272

NM_010071

RefSeq (protein)

NP_001304729
NP_003965
NP_958728

NP_034201
NP_001388209
NP_001388210

Location (UCSC)Chr 8: 21.91 – 21.91 MbChr 14: 70.77 – 70.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Docking protein 2 is a protein that in humans is encoded by the DOK2 gene.[5][6][7]

Function

The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.[7]

Interactions

DOK2 has been shown to interact with INPP5D[8] and TEK tyrosine kinase.[9][10]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000147443 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022102 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Di Cristofano A, Carpino N, Dunant N, Friedland G, Kobayashi R, Strife A, Wisniewski D, Clarkson B, Pandolfi PP, Resh MD (March 1998). "Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins". J Biol Chem. 273 (9): 4827–30. doi:10.1074/jbc.273.9.4827. PMID 9478921.
  6. Garcia A, Prabhakar S, Hughan S, Anderson TW, Brock CJ, Pearce AC, Dwek RA, Watson SP, Hebestreit HF, Zitzmann N (March 2004). "Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins". Blood. 103 (6): 2088–95. doi:10.1182/blood-2003-07-2392. PMID 14645010.
  7. 1 2 "Entrez Gene: DOK2 docking protein 2, 56kDa".
  8. Dunant NM, Wisniewski D, Strife A, Clarkson B, Resh MD (2000). "The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells". Cell. Signal. 12 (5): 317–26. doi:10.1016/S0898-6568(00)00073-5. PMID 10822173.
  9. Jones N, Dumont DJ (1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R". Oncogene. 17 (9): 1097–108. doi:10.1038/sj.onc.1202115. PMID 9764820. S2CID 20187169.
  10. Master Z, Jones N, Tran J, Jones J, Kerbel RS, Dumont DJ (2001). "Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak". EMBO J. 20 (21): 5919–28. doi:10.1093/emboj/20.21.5919. PMC 125712. PMID 11689432.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.