DDX46
Identifiers
AliasesDDX46, PRPF5, Prp5, DEAD-box helicase 46
External IDsOMIM: 617848 MGI: 1920895 HomoloGene: 5430 GeneCards: DDX46
Orthologs
SpeciesHumanMouse
Entrez

9879

212880

Ensembl

ENSG00000145833

ENSMUSG00000021500

UniProt

Q7L014

Q569Z5

RefSeq (mRNA)

NM_001300860
NM_014829

NM_001282055
NM_145975

RefSeq (protein)

NP_001287789
NP_055644

NP_001268984

Location (UCSC)Chr 5: 134.76 – 134.86 MbChr 13: 55.78 – 55.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable ATP-dependent RNA helicase DDX46 is an enzyme that in humans is encoded by the DDX46 gene.[5]

Function

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the 17S U2 snRNP complex; it plays an important role in pre-mRNA splicing.[5]

Interactions

DDX46 has been shown to interact with SF3A2.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000145833 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021500 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46".
  6. Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R (Sep 2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". EMBO J. 21 (18): 4978–88. doi:10.1093/emboj/cdf480. PMC 126279. PMID 12234937.

Further reading


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