DCTN5

DCTN5
Identifiers
Aliases	DCTN5, dynactin subunit 5
External IDs	OMIM: 612962 MGI: 1891689 HomoloGene: 10998 GeneCards: DCTN5
Gene location (Human)
Chr.	Chromosome 16 (human)
End	23,677,472 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	121,748,267 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; rectum; ; stromal cell of endometrium; ; smooth muscle tissue; ; monocyte; ; ganglionic eminence; ; lymph node; ; gallbladder; ; skin of abdomen; ; gastrocnemius muscle;
	Top expressed in
	superior frontal gyrus; ; medial ganglionic eminence; ; yolk sac; ; pituitary gland; ; cumulus cell; ; blood; ; internal carotid artery; ; thymus; ; proximal tubule; ; external carotid artery;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; cytosol; centrosome; nuclear membrane; chromosome, centromeric region; cytoskeleton; kinetochore; nucleoplasm; chromosome;
Biological process	endoplasmic reticulum to Golgi vesicle-mediated transport; aorta development; ventricular septum development; antigen processing and presentation of exogenous peptide antigen via MHC class II; coronary vasculature development;
	Sources:Amigo / QuickGO
Orthologs
	84516
	59288
	ENSG00000166847
	ENSMUSG00000030868
	Q9BTE1
	Q9QZB9
	NM_001199011; NM_001199743; NM_032486
	NM_021608
	NP_001185940; NP_001186672; NP_115875
	NP_067621
	Wikidata
View/Edit Human	View/Edit Mouse

Dynactin 5 (p25) is a protein that in humans is encoded by the DCTN5 gene.^[5]

This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166847 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030868 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: Dynactin 5 (p25)". Retrieved 2011-09-20.

Eckley, D. M.; Gill, S. R.; Melkonian, K. A.; Bingham, J. B.; Goodson, H. V.; Heuser, J. E.; Schroer, T. A. (1999). "Analysis of Dynactin Subcomplexes Reveals a Novel Actin-Related Protein Associated with the Arp1 Minifilament Pointed End". The Journal of Cell Biology. 147 (2): 307–320. doi:10.1083/jcb.147.2.307. PMC 2174220. PMID 10525537. Parisi, G.; Fornasari, M.; Echave, J. (2004). "Dynactins p25 and p27 are predicted to adopt the L?H fold". FEBS Letters. 562 (1–3): 1–4. doi:10.1016/S0014-5793(04)00165-6. PMID 15043994. S2CID 84381211. Burton, P. R.; et al. (2007). "Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls". Nature. 447 (7145): 661–678. Bibcode:2007Natur.447..661B. doi:10.1038/nature05911. PMC 2719288. PMID 17554300.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166847 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030868 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: Dynactin 5 (p25)". Retrieved 2011-09-20.

[1]

[2]

[3]

[4]

[5]

References

Further reading