CLK2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCLK2, CDC like kinase 2
External IDsOMIM: 602989 MGI: 1098669 HomoloGene: 33303 GeneCards: CLK2
Orthologs
SpeciesHumanMouse
Entrez

1196

12748

Ensembl

ENSG00000261893
ENSG00000176444

ENSMUSG00000068917

UniProt

P49760

O35491

RefSeq (mRNA)

NM_001291
NM_001294338
NM_001294339
NM_003993
NM_001363704

NM_001163432
NM_007712

RefSeq (protein)

NP_001281267
NP_001281268
NP_003984
NP_001350633

NP_001156904
NP_031738

Location (UCSC)Chr 1: 155.26 – 155.28 MbChr 3: 89.07 – 89.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dual specificity protein kinase CLK2 is an enzyme that in humans is encoded by the CLK2 gene.[5][6][7]

Function

This gene encodes a member of the CLK family of dual specificity protein kinases. CLK family members have shown to interact with, and phosphorylate, serine/arginine-rich (SR) proteins of the spliceosomal complex, which is a part of the regulatory mechanism that enables the SR proteins to control RNA splicing. This protein kinase is involved in the regulation of several cellular processes and may serve as a link between cell cycle progression, apoptosis, and telomere length regulation.[7]

References

  1. 1 2 3 ENSG00000176444 GRCh38: Ensembl release 89: ENSG00000261893, ENSG00000176444 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000068917 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hanes J, von der Kammer H, Klaudiny J, Scheit KH (Dec 1994). "Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases". Journal of Molecular Biology. 244 (5): 665–72. doi:10.1006/jmbi.1994.1763. PMID 7990150.
  6. Talmadge CB, Finkernagel S, Sumegi J, Sciorra L, Rabinow L (Oct 1998). "Chromosomal mapping of three human LAMMER protein-kinase-encoding genes". Human Genetics. 103 (4): 523–4. doi:10.1007/s004390050861. PMID 9856501. S2CID 40593571.
  7. 1 2 "Entrez Gene: CLK2 CDC-like kinase 2".

Further reading

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