CLCF1
Identifiers
AliasesCLCF1, BSF-3, BSF3, CISS2, CLC, NNT-1, NNT1, NR6, cardiotrophin-like cytokine factor 1, cardiotrophin like cytokine factor 1
External IDsOMIM: 607672 MGI: 1930088 HomoloGene: 8299 GeneCards: CLCF1
Orthologs
SpeciesHumanMouse
Entrez

23529

56708

Ensembl

ENSG00000175505

ENSMUSG00000040663

UniProt

Q9UBD9

Q9QZM3

RefSeq (mRNA)

NM_013246
NM_001166212

NM_019952
NM_001310038
NM_001310039

RefSeq (protein)

NP_001159684
NP_037378

NP_001296967
NP_001296968
NP_064336

Location (UCSC)Chr 11: 67.36 – 67.37 MbChr 19: 4.26 – 4.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cardiotrophin-like cytokine factor 1 (CLCF1), also known as Novel Neurotrophin-1 (NNT-1) or B cell-stimulating factor-3 (BSF-3), is a protein that in humans is encoded by the CLCF1 gene.[5]

Function

CLCF1 is a cytokine. It induces tyrosine phosphorylation of the IL-6 receptor common subunit glycoprotein 130 (gp130), leukemia inhibitory factor receptor beta, and the transcription factor STAT3. It has been implicated in the induction of IL-1 (via induction of corticosterone and IL-6) and serum amyloid A, and in B cell hyperplasia. CLCF1 is capable of B cell activation via gp130 receptor stimulation.[6]

Structure

CLCF1 is a cytokine belonging to the interleukin-6 (IL6) family. It is a secreted protein, found predominantly in lymph nodes and spleen, and contains 225 amino acids with a molecular mass of 22 kDa in its mature form. IL6 family members share similarity in gene structure and have a 4-helix bundle in their protein structure. CLCF1 is closely related to other proteins called cardiotrophin-1 and ciliary neurotrophic factor.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000175505 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040663 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: CLCF1 cardiotrophin-like cytokine factor 1".
  6. Senaldi G, Varnum BC, Sarmiento U, Starnes C, Lile J, Scully S, Guo J, Elliott G, McNinch J, Shaklee CL, Freeman D, Manu F, Simonet WS, Boone T, Chang MS (September 1999). "Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11458–63. Bibcode:1999PNAS...9611458S. doi:10.1073/pnas.96.20.11458. PMC 18055. PMID 10500198.

Further reading


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