CEP350
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCEP350, CAP350, GM133, centrosomal protein 350
External IDsOMIM: 617870 MGI: 1921331 HomoloGene: 8879 GeneCards: CEP350
Orthologs
SpeciesHumanMouse
Entrez

9857

74081

Ensembl

ENSG00000135837

ENSMUSG00000033671

UniProt

Q5VT06

E9Q309

RefSeq (mRNA)

NM_014810

NM_001039184

RefSeq (protein)

NP_055625

NP_001034273

Location (UCSC)Chr 1: 179.95 – 180.11 MbChr 1: 155.72 – 155.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centrosome-associated protein 350 is a protein that in humans is encoded by the CEP350 gene.[5][6][7]

CEP350 is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. It primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. CEP350 is required to anchor microtubules at the centrosome. Furthermore, it increases the stability of growing centrioles.[8]

It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000135837 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033671 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Yan X, Habedanck R, Nigg EA (Jan 2006). "A Complex of Two Centrosomal Proteins, CAP350 and FOP, Cooperates with EB1 in Microtubule Anchoring". Mol Biol Cell. 17 (2): 634–44. doi:10.1091/mbc.E05-08-0810. PMC 1356575. PMID 16314388.
  6. Patel H, Truant R, Rachubinski RA, Capone JP (Dec 2004). "Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome-associated protein CAP350". J Cell Sci. 118 (Pt 1): 175–86. doi:10.1242/jcs.01600. PMID 15615782.
  7. 1 2 "Entrez Gene: CEP350 centrosomal protein 350kDa".
  8. Le Clech, M (2008). "Role of CAP350 in centriolar tubule stability and centriole assembly". PLOS ONE. 3 (12): e3855. Bibcode:2008PLoSO...3.3855L. doi:10.1371/journal.pone.0003855. PMC 2586089. PMID 19052644.

Further reading


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