CDS2
Identifiers
AliasesCDS2, CDP-diacylglycerol synthase 2
External IDsOMIM: 603549 MGI: 1332236 HomoloGene: 37854 GeneCards: CDS2
Orthologs
SpeciesHumanMouse
Entrez

8760

110911

Ensembl

ENSG00000101290

ENSMUSG00000058793

UniProt

O95674

Q99L43

RefSeq (mRNA)

NM_003818

NM_001291039
NM_001291040
NM_138651

RefSeq (protein)

NP_003809

NP_001277968
NP_001277969
NP_619592

Location (UCSC)Chr 20: 5.13 – 5.2 MbChr 2: 132.11 – 132.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Phosphatidate cytidylyltransferase 2 is an enzyme that in humans is encoded by the CDS2 gene.[5][6][7]

Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin.[8][9] and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 (CDS1) and a second (this gene) to 20p13.[10]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000101290 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000058793 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Halford S, Dulai KS, Daw SC, Fitzgibbon J, Hunt DM (Nov 1998). "Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes". Genomics. 54 (1): 140–4. doi:10.1006/geno.1998.5547. PMID 9806839.
  6. Volta M, Bulfone A, Gattuso C, Rossi E, Mariani M, Consalez GG, Zuffardi O, Ballabio A, Banfi S, Franco B (Jan 1999). "Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene". Genomics. 55 (1): 68–77. doi:10.1006/geno.1998.5610. PMID 9889000.
  7. "Entrez Gene: CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2".
  8. Nowicki M, Müller F, Frentzen M (Apr 2005). "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters. 579 (10): 2161–5. doi:10.1016/j.febslet.2005.03.007. PMID 15811335. S2CID 21937549.
  9. Nowicki M (2006). "Characterization of the Cardiolipin Synthase from Arabidopsis thaliana". Ph.D. Thesis, RWTH-Aachen University. Archived from the original on 2011-10-05. Retrieved 2011-07-11.
  10. "Entrez Gene: CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1".

Further reading

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