CDC42BPA
Identifiers
AliasesCDC42BPA, MRCK, MRCKA, PK428, CDC42 binding protein kinase alpha
External IDsOMIM: 603412 MGI: 2441841 HomoloGene: 55765 GeneCards: CDC42BPA
Orthologs
SpeciesHumanMouse
Entrez

8476

226751

Ensembl

ENSG00000143776

ENSMUSG00000026490

UniProt

Q5VT25

Q3UU96

RefSeq (mRNA)
RefSeq (protein)

NP_003598
NP_055641
NP_001352939
NP_001352940
NP_001352948

Location (UCSC)Chr 1: 226.99 – 227.32 MbChr 1: 179.79 – 179.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase MRCK alpha is an enzyme that in humans is encoded by the CDC42BPA gene.[5]

The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000143776 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026490 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.