CCNG1
Identifiers
AliasesCCNG1, cyclin G1, CCNG
External IDsOMIM: 601578 MGI: 102890 HomoloGene: 2995 GeneCards: CCNG1
Orthologs
SpeciesHumanMouse
Entrez

900

12450

Ensembl

ENSG00000113328

ENSMUSG00000020326

UniProt

P51959

P51945

RefSeq (mRNA)

NM_004060
NM_199246

NM_009831

RefSeq (protein)

NP_033961

Location (UCSC)Chr 5: 163.44 – 163.45 MbChr 11: 40.64 – 40.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cyclin-G1 is a protein that in humans is encoded by the CCNG1 gene.[5][6][7]

Function

The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene.[7]

Interactions

CCNG1 has been shown to interact with:

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000113328 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020326 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Endo Y, Fujita T, Tamura K, Tsuruga H, Nojima H (1996). "Structure and chromosomal assignment of the human cyclin G gene". Genomics. 38 (1): 92–5. doi:10.1006/geno.1996.0598. PMID 8954786.
  6. Bates S, Rowan S, Vousden KH (Nov 1996). "Characterisation of human cyclin G1 and G2: DNA damage inducible genes". Oncogene. 13 (5): 1103–9. PMID 8806701.
  7. 1 2 "Entrez Gene: CCNG1 cyclin G1".
  8. 1 2 3 Zhao L, Samuels T, Winckler S, Korgaonkar C, Tompkins V, Horne MC, Quelle DE (Jan 2003). "Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways". Mol. Cancer Res. 1 (3): 195–206. PMID 12556559.
  9. Okamoto K, Kamibayashi C, Serrano M, Prives C, Mumby MC, Beach D (Nov 1996). "p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A". Mol. Cell. Biol. 16 (11): 6593–602. doi:10.1128/mcb.16.11.6593. PMC 231661. PMID 8887688.

Further reading


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