CALY
Identifiers
AliasesCALY, DRD1IP, NSG3, calcyon neuron specific vesicular protein
External IDsOMIM: 604647 MGI: 1915816 HomoloGene: 9256 GeneCards: CALY
Orthologs
SpeciesHumanMouse
Entrez

50632

68566

Ensembl

ENSG00000130643

ENSMUSG00000025468

UniProt

Q9NYX4

Q9DCA7

RefSeq (mRNA)

NM_015722
NM_001321617

NM_001190385
NM_001190386
NM_026769

RefSeq (protein)

NP_001308546
NP_056537

NP_001177314
NP_001177315
NP_081045

Location (UCSC)Chr 10: 133.32 – 133.34 MbChr 7: 139.65 – 139.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuron-specific vesicular protein calcyon is a protein that in humans is encoded by the CALY gene.[5][6] Its alternative name is Calcyon.

Function

The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with dopamine receptor D1 and may interact with other DA receptor subtypes and/or GPCRs.[6]

Interactions

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000130643 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025468 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Heijtz RD, Alexeyenko A, Castellanos FX (July 2007). "Calcyon mRNA expression in the frontal-striatal circuitry and its relationship to vesicular processes and ADHD". Behavioral and Brain Functions. 3 (1): 33. doi:10.1186/1744-9081-3-33. PMC 1949817. PMID 17623072.
  6. 1 2 "CALY calcyon neuron specific vesicular protein [ Homo sapiens (human) ]".
  7. Kim JH, Jung HG, Kim A, Shim HS, Hyeon SJ, Lee YS, et al. (March 2021). "Hevin-calcyon interaction promotes synaptic reorganization after brain injury". Cell Death and Differentiation. 28 (9): 2571–2588. doi:10.1038/s41418-021-00772-5. PMC 8408247. PMID 33753902.

Further reading


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