C11orf91
Identifiers
AliasesC11orf91, chromosome 11 open reading frame 91
External IDsMGI: 1915493 HomoloGene: 41690 GeneCards: C11orf91
Orthologs
SpeciesHumanMouse
Entrez

100131378

68243

Ensembl

ENSG00000205177

ENSMUSG00000032671

UniProt

Q3C1V1

Q9D1Z2

RefSeq (mRNA)

NM_001166692

NM_026634

RefSeq (protein)

NP_001160164

NP_080910

Location (UCSC)Chr 11: 33.7 – 33.7 MbChr 2: 103.95 – 103.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Chromosome 11 open reading frame 91, or C11orf91 is a protein which in humans is encoded by the C11orf91 gene.

Gene

Conceptual translation of human C11orf91 gene/protein.

The C11orf91 gene consists of 5159 nucleotides with an mRNA of approximately 836 base pairs.[5][6] There is one exon found in the C11orf91 gene.

mRNA

The cytogenetic band location of C11orf91 is 11p13 and is located on the minus strand of the DNA .[7]

Conceptual translation

Annotated depiction of the C11orf91 mRNA and amino acid protein sequences.

Protein

Tertiary Structure of human C11orf91 protein. Created with AlphaFold Protein Structure Database.[8]

The C11orf91 gene encodes a protein that is 193 amino acids in length.[9][10] The C11orf91 protein contains a domain of unknown function, DUF5529, that spans nearly the entire protein. RBMX protein binding sites were found to be highly conserved in several structures of human C11orf91 3'UTR and 5' UTR.[11][12] C11orf91 is rich in serine and proline and poor in valine and asparagine.[13] There is a proline rich region found in the middle of the C11orf91.[14] The human C11orf91 protein is approximately 20 kDal and has an isoelectric point around 9.[15]

Localization

Human C11orf91 protein is predicted to be localized in vesicles.[16][17]

Structure

C11orf91 has two helices located near the C-terminus and no beta sheets.[18][19][20][21][22][23][24]

Post-translational modifications

C11orf91 has a predicted Protein kinase C (PKC) phosphorylation site, Casein kinase 2 (CK2) phosphorylation site, amidation site, and two predicted serine phosphorylation sites, see Conceptual Translation for post-translational modification site locations.[25][26][27][28]

Evolution

Corrected Sequence Divergence vs. Median Date of Divergence graph for human C11orf91, Fibrinogen Alpha, and Cytochrome C.

There are no paralogs of the human C11orf91 protein.[29][30] The human C11orf91 protein has several orthologs found across eight categories of jawed vertebrates including: aves, testudines, alligators, reptiles, mammals, amphibians, lungfishes, and cartilaginous fishes.[31]

Select Orthologs of C11orf91
Genus and SpeciesCommon NameTaxonomic GroupMedian Date of Divergence (MYA)Accession NumberSequence Length (aa)Sequence Identity to Human Protein (%)Sequence Similarity to Human Protein (%)
Homo sapeinsHumanPrimates0XP_016872542.1193100100
Mus musculusMouseRodentia87NP_080910.119481.784.3
Equus caballusHorseOdd-toed ungulates94XP_023509601.11918789.1
Choloepus didactylusSouthern two-toed slothPilosa99XP_037697448.119186.287.2
Phascolarctos cinereusKoalaDiprotodontia160XP_020819588.121267.170.8
Gopherus evgoodeiGoode's thornscrub tortoiseTestudines319XP_030417986.116346.555.5
Pogona vitticepsCentral bearded dragonSquamata319XP_020663275.116844.354.7
Sphaerodactylus townsendiTownsend's least geckoSquamata319XP_048340539.11684351.7
Alligator mississippiensisAmerican alligatorCrocodilia319XP_059577366.115741.451.2
Tyto albaBarn owlStrigiformes319XP_042641164.114334.541.5
Calypte annaHummingbirdApodiformes319XP_030307391.114632.344.6
Gymnogyps californianusCalifornia condorAccipitriformes319XP_050754406.114232.238.8
Dryobates pubescensDowny woodpeckerPiciformes319XP_054027854.114332.143.5
Dromaius novaehollandiaeEmuStruthioniformes319XP_025967391.120929.635.8
Rhinatrema bivittatumTwo-lined caeciliansCaecilidae352XP_029438087.114445.157
Pleurodeles waltlIberian ribbed newtCaudata352KAJ1177600.114040.152.3
Hyla sardaSardinian tree frogAnura352XP_056384394.115327.437
Protopterus annectensWest African lungfishLepidosireniformes408XP_043915714.117328.537.4
Pygocentrus nattereriRed-bellied piranhaCharaciformes429XP_017546298.114725.937.1
Amblyraja radiataThorny skateRajiformes462XP_032894439.113637.746.2

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000205177 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032671 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Human chromosome 11 open reading frame 91 (C11orf91), mRNA. NCBI Nucleotide. Retrieved 23 September 2023.
  6. ↑ Uncharacterized protein C11orf91 [Homo sapiens]. NCBI Protein. Retrieved 23 September 2023.
  7. ↑ C11orf91 Gene. Gene Cards. Retrieved 23 September 2023.
  8. ↑ AlphaFold Protein Structure Database. AlphaFold Protein Structure Database. Retrieved 5 December 2023.
  9. ↑ Homo sapiens chromosome 11 open reading frame 91 (C11orf91), mRNA. NCBI Nucleotide. Retrieved 23 September 2023.
  10. ↑ Uncharacterized protein C11orf91 [Homo sapiens]. NCBI Protein. Retrieved 23 September 2023.
  11. ↑ RNA Folding Form Tool. The UNAFold Web Server. Retrieved 5 December 2023.
  12. ↑ Predict Binding Sites from PWMs Tool. RBPDB.Retrieved 5 December 2023.
  13. ↑ Statistical Analysis of Protein Sequences Tool. European Bioinformatics Institute. Retrieved 5 December 2023.
  14. ↑ Homo sapiens chromosome 11 open reading frame 91 (C11orf91), mRNA. NCBI Nucleotide. Retrieved 5 December 2023.
  15. ↑ PhosphoSitePlus Tool. PhosphoSitPlus. Retrieved 15 December 2023.
  16. ↑ C11orf91 Polyclonal Antibody. ThermoFisher Scientific. Retrieved 5 December 2023.
  17. ↑ The Human Protein Atlas entry on C11orf91. Human Protein Atlas. Retrieved 5 December 2023.
  18. ↑ Chou & Fasman Secondary Structure Prediction Server. Biogem. Retrieved 5 December 2023.
  19. ↑ JPred 4: A Protein Secondary Structure Prediction Server. JPred 4. Retrieved 5 December 2023.
  20. ↑ Predict Protein Tool. Predictprotein. Retrieved 5 December 2023.
  21. ↑ Ali2D Tool. MPI Bioinformatics Toolkit. Retrieved 5 December 2023.
  22. ↑ I-TASSER Tool. The Yang Zhang Lab. Retrieved 5 December 2023.
  23. ↑ AlphaFold Protein Structure Database. AlphaFold Protein Structure Database. Retrieved 5 December 2023.
  24. ↑ NCBI Structure iCN3D. iCn3D: Web-based 3D Structure Viewer. Retrieved 5 December 2023.
  25. ↑ MyHits Motif Scan Tool. SIB Swiss Institute of Bioinformatics. Retrieved 5 December 2023.
  26. ↑ DTU Health Tech NetPhos 3.1 Tool. DTU Health Tech Department of Health Technology. Retrieved 5 December 2023.
  27. ↑ GPS 6.0. Group Based Prediction System. Retrieved 5 December 2023.
  28. ↑ PhosphoSitePlus Tool. Phosphosite. Retrieved 5 December 2023.
  29. ↑ (National Center for Biotechnology Information) Basic Local Alignment Search Tool. NCBI BLAST. Retrieved 5 December 2023.
  30. ↑ UCSC Genome Browser entry on Human GRCh38/hg38. UCSC Genome Browser. Retrieved 5 December 2023.
  31. ↑ NCBI (National Center for Biotechnology Information) entry on C11orf91 - chromosome 11 open reading frame 91 NCBI Orthologs . NCBI Protein. Retrieved 19 October 2023.
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