BICD1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBICD1, BICD, BICD cargo adaptor 1, bic-D 1
External IDsOMIM: 602204 MGI: 1101760 HomoloGene: 37518 GeneCards: BICD1
Orthologs
SpeciesHumanMouse
Entrez

636

12121

Ensembl

ENSG00000151746

ENSMUSG00000003452

UniProt

Q96G01

Q8BR07

RefSeq (mRNA)

NM_001112796
NM_009753

RefSeq (protein)

NP_001106267
NP_033883

Location (UCSC)Chr 12: 32.11 – 32.38 MbChr 6: 149.31 – 149.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Bicaudal D cargo adaptor 1 is a protein that in humans is encoded by the BICD1 gene.[5][6]

Function

This gene is one of two human homologs of Drosophila bicaudal-D. It has been implicated in COPI-independent membrane transport from the Golgi apparatus to the endoplasmic reticulum. Two alternative splice variants have been described. Other alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.[6]

Interactions

BICD1 has been shown to interact with RAB6A.[7][8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000151746 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003452 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Baens M, Marynen P (Nov 1997). "A human homologue (BICD1) of the Drosophila bicaudal-D gene". Genomics. 45 (3): 601–6. doi:10.1006/geno.1997.4971. PMID 9367685.
  6. 1 2 "Entrez Gene: BICD1 bicaudal D homolog 1 (Drosophila)".
  7. Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA (Oct 2002). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Current Biology. 12 (20): 1792–5. doi:10.1016/S0960-9822(02)01221-6. PMID 12401177. S2CID 14031165.
  8. Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC (December 2002). "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex". Nature Cell Biology. 4 (12): 986–92. doi:10.1038/ncb891. PMID 12447383. S2CID 7953140.

Further reading


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