BCL7A
Identifiers
AliasesBCL7A, BCL7, B-cell CLL/lymphoma 7A, BCL tumor suppressor 7A, BAF complex component, BAF chromatin remodeling complex subunit SMARCJ1
External IDsOMIM: 601406 MGI: 1924295 HomoloGene: 10869 GeneCards: BCL7A
Orthologs
SpeciesHumanMouse
Entrez

605

77045

Ensembl

ENSG00000282873
ENSG00000110987

ENSMUSG00000029438

UniProt

Q4VC05

Q9CXE2

RefSeq (mRNA)

NM_020993
NM_001024808

NM_029850

RefSeq (protein)

NP_001019979
NP_066273

NP_084126

Location (UCSC)Chr 12: 122.02 – 122.06 MbChr 5: 123.48 – 123.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

B-cell CLL/lymphoma 7 protein family member A is a protein that in humans is encoded by the BCL7A gene. [5]

Function

This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene.

See also

References

  1. 1 2 3 ENSG00000110987 GRCh38: Ensembl release 89: ENSG00000282873, ENSG00000110987 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029438 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "BCL7A BAF chromatin remodeling complex subunit BCL7A [ Homo sapiens (human) ]". Retrieved 2019-04-28.

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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