AUP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAUP1, ancient ubiquitous protein 1, lipid droplet regulating VLDL assembly factor, AUP1 lipid droplet regulating VLDL assembly factor
External IDsOMIM: 602434 MGI: 107789 HomoloGene: 7239 GeneCards: AUP1
Orthologs
SpeciesHumanMouse
Entrez

550

11993

Ensembl

ENSG00000115307

ENSMUSG00000068328

UniProt

Q9Y679

P70295

RefSeq (mRNA)

NM_181575

NM_001025446
NM_001301649
NM_007517

RefSeq (protein)

NP_853553

NP_001288578
NP_031543

Location (UCSC)Chr 2: 74.53 – 74.53 MbChr 6: 83.03 – 83.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ancient ubiquitous protein 1 is a protein that in humans is encoded by the AUP1 gene.[5][6][7]

Function

This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha (IIb) subunits. These subunits play a crucial role in the integrin alpha (IIb) beta (3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25.[7]

Interactions

AUP1 has been shown to interact with ITGA2B.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000115307 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000068328 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Jang W, Weber JS, Bashir R, Bushby K, Meisler MH (Jan 1997). "Aup1, a novel gene on mouse chromosome 6 and human chromosome 2p13". Genomics. 36 (2): 366–8. doi:10.1006/geno.1996.0477. PMID 8812468.
  6. 1 2 Kato A, Kawamata N, Tamayose K, Egashira M, Miura R, Fujimura T, Murayama K, Oshimi K (Aug 2002). "Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3". J Biol Chem. 277 (32): 28934–41. doi:10.1074/jbc.M204340200. PMID 12042322.
  7. 1 2 "Entrez Gene: AUP1 ancient ubiquitous protein 1".

Further reading


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