ATP6V0B
Identifiers
AliasesATP6V0B, ATP6F, HATPL, VMA16, ATPase H+ transporting V0 subunit b
External IDsOMIM: 603717 MGI: 1890510 HomoloGene: 2986 GeneCards: ATP6V0B
Orthologs
SpeciesHumanMouse
Entrez

533

114143

Ensembl

ENSG00000117410

ENSMUSG00000033379

UniProt

Q99437

Q91V37

RefSeq (mRNA)

NM_004047
NM_001039457
NM_001294333

NM_033617

RefSeq (protein)

NP_001034546
NP_001281262
NP_004038

NP_291095

Location (UCSC)Chr 1: 43.97 – 43.98 MbChr 4: 117.74 – 117.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

V-type proton ATPase 21 kDa proteolipid subunit is an enzyme that in humans is encoded by the ATP6V0B gene.[5][6]

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits, plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d.

Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes, or alternatively spliced transcript variants. This encoded protein is part of the transmembrane V0 domain, and is the human counterpart of yeast VMA16. Two alternatively spliced transcript variants that encode different proteins have been found for this gene.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000117410 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033379 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nishigori H, Yamada S, Tomura H, Fernald AA, Le Beau MM, Takeuchi T, Takeda J (Oct 1998). "Identification and characterization of the gene encoding a second proteolipid subunit of human vacuolar H(+)-ATPase (ATP6F)". Genomics. 50 (2): 222–8. doi:10.1006/geno.1998.5310. PMID 9653649.
  6. 1 2 "Entrez Gene: ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b".

Further reading


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