ARHGEF4

ARHGEF4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DX1, 2PZ1, 3NMX, 3NMZ
Identifiers
Aliases	ARHGEF4, ASEF, ASEF1, GEF4, STM6, Rho guanine nucleotide exchange factor 4, SMIM39
External IDs	OMIM: 605216 MGI: 2442507 HomoloGene: 49414 GeneCards: ARHGEF4
Gene location (Human)
Chr.	Chromosome 2 (human)
End	131,047,263 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	34,813,309 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; prefrontal cortex; ; Brodmann area 9; ; cingulate gyrus; ; amygdala; ; putamen; ; caudate nucleus; ; Brodmann area 10; ; middle frontal gyrus; ; hippocampus proper;
	Top expressed in
	pontine nuclei; ; dorsal tegmental nucleus; ; anterior horn of spinal cord; ; medial vestibular nucleus; ; superior colliculus; ; hippocampus proper; ; dentate gyrus; ; facial motor nucleus; ; prefrontal cortex; ; globus pallidus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein domain specific binding; guanyl-nucleotide exchange factor activity;
Cellular component	cytoplasm; ruffle membrane; cytosol; plasma membrane; cell projection; membrane;
Biological process	filopodium assembly; regulation of Rho protein signal transduction; intracellular signal transduction; regulation of small GTPase mediated signal transduction; lamellipodium assembly; positive regulation of apoptotic process; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	50649
	226970
	ENSG00000136002
	ENSMUSG00000037509
	Q9NR80
	Q7TNR9
NM_015320; NM_032995; NM_001367493; NM_001375900; NM_001375901;
	NM_001375902; NM_001375903; NM_001375904; NM_001395416
	NM_183019; NM_001368773
NP_056135; NP_001354422; NP_001362829; NP_001362830; NP_001362831;
	NP_001362832; NP_001362833
	NP_898840; NP_001355702
	Wikidata
View/Edit Human	View/Edit Mouse

Rho guanine nucleotide exchange factor 4 is a protein that in humans is encoded by the ARHGEF4 gene.^[5]^[6]

Function

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to rat collybistin protein. Alternative splicing of this gene generates two transcript variants that encode different isoforms. Also, there is possibility for the usage of multiple polyadenylation sites for this gene.^[6]

Interactions

ARHGEF4 has been shown to interact with APC.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000136002 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037509 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Thiesen S, Kübart S, Ropers HH, Nothwang HG (Jul 2000). "Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22". Biochem Biophys Res Commun. 273 (1): 364–9. doi:10.1006/bbrc.2000.2925. PMID 10873612.
1 2 "Entrez Gene: ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4".
↑ Kawasaki Y, Senda T, Ishidate T, Koyama R, Morishita T, Iwayama Y, Higuchi O, Akiyama T (2000). "Asef, a link between the tumor suppressor APC and G-protein signaling". Science. 289 (5482): 1194–7. Bibcode:2000Sci...289.1194K. doi:10.1126/science.289.5482.1194. PMID 10947987.

External links

Human ARHGEF4 genome location and ARHGEF4 gene details page in the UCSC Genome Browser.

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Kuraguchi M, Wang XP, Bronson RT, et al. (2006). "Adenomatous polyposis coli (APC) is required for normal development of skin and thymus". PLOS Genet. 2 (9): e146. doi:10.1371/journal.pgen.0020146. PMC 1564426. PMID 17002498.
Watanabe T, Wang S, Noritake J, et al. (2005). "Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration". Dev. Cell. 7 (6): 871–83. doi:10.1016/j.devcel.2004.10.017. PMID 15572129.
Kawasaki Y, Sato R, Akiyama T (2003). "Mutated APC and Asef are involved in the migration of colorectal tumour cells". Nat. Cell Biol. 5 (3): 211–5. doi:10.1038/ncb937. PMID 12598901. S2CID 22276128.
Kawasaki Y, Senda T, Ishidate T, et al. (2000). "Asef, a link between the tumor suppressor APC and G-protein signaling". Science. 289 (5482): 1194–7. Bibcode:2000Sci...289.1194K. doi:10.1126/science.289.5482.1194. PMID 10947987.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000136002 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037509 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10873612-5] Thiesen S, Kübart S, Ropers HH, Nothwang HG (Jul 2000). "Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22". Biochem Biophys Res Commun. 273 (1): 364–9. doi:10.1006/bbrc.2000.2925. PMID 10873612.

[entrez-6] 1 2 "Entrez Gene: ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4".

[pmid10947987-7] Kawasaki Y, Senda T, Ishidate T, Koyama R, Morishita T, Iwayama Y, Higuchi O, Akiyama T (2000). "Asef, a link between the tumor suppressor APC and G-protein signaling". Science. 289 (5482): 1194–7. Bibcode:2000Sci...289.1194K. doi:10.1126/science.289.5482.1194. PMID 10947987.

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Function

Interactions

References

External links

Further reading