ARFRP1
Identifiers
AliasesARFRP1, ARL18, ARP, Arp1, ADP ribosylation factor related protein 1
External IDsOMIM: 604699 MGI: 1923938 HomoloGene: 2425 GeneCards: ARFRP1
Orthologs
SpeciesHumanMouse
Entrez

10139

76688

Ensembl

ENSG00000101246

ENSMUSG00000038671

UniProt

Q13795

Q8BXL7

RefSeq (mRNA)

NM_001165991
NM_001165992
NM_001165995
NM_029702

RefSeq (protein)

NP_001159463
NP_001159464
NP_001159467
NP_083978

Location (UCSC)Chr 20: 63.7 – 63.71 MbChr 2: 181 – 181.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ADP-ribosylation factor-related protein 1 is a protein that in humans is encoded by the ARFRP1 gene.[5][6]

Function

The protein encoded by this gene is a membrane-associated GTP-ase and localizes to the plasma membrane. It is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) genes. The gene is located in a gene cluster that includes the a gene (M68) that is overexpressed in some tumors.[6]

Interactions

ARFRP1 has been shown to interact with PSCD1.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000101246 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038671 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Schurmann A, Massmann S, Joost HG (Jan 1996). "ARP is a plasma membrane-associated Ras-related GTPase with remote similarity to the family of ADP-ribosylation factors". J Biol Chem. 270 (51): 30657–63. doi:10.1074/jbc.270.51.30657. PMID 8530503.
  6. 1 2 "Entrez Gene: ARFRP1 ADP-ribosylation factor related protein 1".
  7. Schürmann A, Schmidt M, Asmus M, Bayer S, Fliegert F, Koling S, Massmann S, Schilf C, Subauste MC, Voss M, Jakobs KH, Joost HG (April 1999). "The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange factor cytohesin and inhibits the ARF-dependent activation of phospholipase D". J. Biol. Chem. 274 (14): 9744–51. doi:10.1074/jbc.274.14.9744. PMID 10092663.

Further reading


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