A4GALT
Identifiers
AliasesA4GALT, A14GALT, A4GALT1, Gb3S, P(k), P1, P1PK, PK, alpha 1,4-galactosyltransferase, alpha 1,4-galactosyltransferase (P blood group)
External IDsOMIM: 607922 MGI: 3512453 HomoloGene: 9690 GeneCards: A4GALT
EC number2.4.1.228
Orthologs
SpeciesHumanMouse
Entrez

53947

239559

Ensembl

ENSG00000128274

ENSMUSG00000047878

UniProt

Q9NPC4

Q67BJ4

RefSeq (mRNA)

NM_017436
NM_001318038

NM_001004150
NM_001170954
NM_001370647

RefSeq (protein)

NP_001304967
NP_059132

NP_001004150
NP_001164425
NP_001357576

Location (UCSC)Chr 22: 42.69 – 42.72 MbChr 15: 83.11 – 83.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lactosylceramide 4-alpha-galactosyltransferase is an enzyme that in humans is encoded by the A4GALT gene.[5][6]

The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. The encoded protein, which is a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000128274 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047878 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Keusch JJ, Manzella SM, Nyame KA, Cummings RD, Baenziger JU (Sep 2000). "Cloning of Gb3 synthase, the key enzyme in globo-series glycosphingolipid synthesis, predicts a family of alpha 1, 4-glycosyltransferases conserved in plants, insects, and mammals". J Biol Chem. 275 (33): 25315–21. doi:10.1074/jbc.M002630200. PMID 10854428.
  6. 1 2 "Entrez Gene: A4GALT alpha 1,4-galactosyltransferase (globotriaosylceramide synthase)".

Further reading



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