Singles
2021 Challenger de Santiago
Champion	Sebastián Báez
Runner-up	Marcelo Tomás Barrios Vera
Score	6–3, 7–6(7–4)

Hugo Dellien was the defending champion^[1] but chose not to defend his title.

Sebastián Báez won the title after defeating Marcelo Tomás Barrios Vera 6–3, 7–6^(7–4) in the final.

Seeds

Draw

Finals

	Semifinals							Final
		Marcelo Tomás Barrios Vera	77	1
		Felipe Meligeni Alves	65	1r
									Marcelo Tomás Barrios Vera	3	64
									Sebastián Báez	6	77
		Sebastián Báez	6	77
		Juan Pablo Varillas	1	63

Top half

	First round							Second round							Quarterfinals							Semifinals
	1	R Carballés Baena	2	6	77
		T Bellucci	6	2	60			1	R Carballés Baena	6	65	68
	WC	G Lama	6	6				WC	G Lama	2	77	710
		TM Etcheverry	4	2											WC	G Lama	64	65
		MT Barrios Vera	4	6	77											MT Barrios Vera	77	77
		C Lindell	6	1	64				MT Barrios Vera	6	6
		O Luz	3	1				7	K Coppejans	4	4
	7	K Coppejans	6	6																			MT Barrios Vera	77	1
	3	P Sousa	6	6																			F Meligeni Alves	65	1r
	LL	R Matos	4	3				3	P Sousa	4	2
		F Meligeni Alves	5	6	7				F Meligeni Alves	6	6
	Q	J Menezes	7	3	5											F Meligeni Alves	6	7
		E Benchetrit	6	6											Q	N Kicker	1	5
		G Blancaneaux	4	4					E Benchetrit	2	4
	Q	N Kicker	6	6				Q	N Kicker	6	6
	5	J Kovalík	2	3

Bottom half

	First round							Second round							Quarterfinals							Semifinals
	6	D Altmaier	6	6
		G Andreozzi	4	3				6	D Altmaier	4	6	3
	Alt	C Ugo Carabelli	6	6				Alt	C Ugo Carabelli	6	3	6
	Q	M Cuevas	4	0											Alt	C Ugo Carabelli	2	1
	WC	H Rune	2	4												S Báez	6	6
		S Báez	6	6					S Báez	7	6
		A Collarini	4	4				Q	G Villanueva	5	2
	Q	G Villanueva	6	6																			S Báez	6	77
	8	A Tabilo	3	2																			JP Varillas	1	63
	WC	N Jarry	6	6				WC	N Jarry	6	6
		N Álvarez	3	6	6				N Álvarez	3	4
		P Sakamoto	6	4	3										WC	N Jarry	2	4
		JP Varillas	6	3	7											JP Varillas	6	6
		R Olivo	4	6	5				JP Varillas	6	69	6
		G Oliveira	62	5				2	A Martin	4	711	4
	2	A Martin	77	7

References

External links

• Main draw
• Qualifying draw