Singles
2010 Serbia Open
Champion	Sam Querrey
Runner-up	John Isner
Score	3–6, 7–6(7–4), 6–4

Sam Querrey defeated John Isner in the final, 3–6, 7–6^(7–4), 6–4 to win the singles tennis title at the 2010 Serbia Open.

Novak Djokovic was the defending champion, but retired in the quarterfinals against Filip Krajinović.

Seeds

The first four seeds gets a first-round bye.

Draw

Finals

	Semifinals							Final
	WC	Filip Krajinović	1	2
	3	Sam Querrey	6	6
								3	Sam Querrey	3	7	6
								2	John Isner	6	64	4
	4	Stanislas Wawrinka	5	5
	2	John Isner	7	7

Top half

	First round							Second round							Quarterfinals							Semifinals
								1	N Djokovic	6	6
		F Fognini	6	6					F Fognini	4	4
	Q	F Škugor	3	1											1	N Djokovic	4	r
	Q	E Donskoy	7	67	1										WC	F Krajinović	6
	WC	F Krajinović	5	7	6			WC	F Krajinović	6	1	7
		H Zeballos	2	6	7				H Zeballos	3	6	65
	LL	P Polansky	6	4	62																	WC	F Krajinović	1	2
																						3	S Querrey	6	6
								3	S Querrey	6	6
		E Korolev	6	6					E Korolev	3	4
		M Russell	1	0											3	S Querrey	6	2	6
		I Andreev	6	6												I Andreev	3	6	4
		B Kavčič	3	2					I Andreev	6	7
	WC	D Lajović	64	4				5	I Karlović	4	5
	5	I Karlović	7	6

Bottom half

	First round							Second round							Quarterfinals							Semifinals
	6	V Troicki	6	6
		I Navarro	4	0				6	V Troicki	6	6
		K Beck	3	3					F Serra	0	1
		F Serra	6	6											6	V Troicki	5	7	66
	WC	M Djokovic	7	5	0										4	S Wawrinka	7	63	7
	Q	A di Mauro	65	7	6			Q	A di Mauro	1	4
								4	S Wawrinka	6	6
																						4	S Wawrinka	5	5
	8	A Seppi	2	6	6																	2	J Isner	7	7
		L Mayer	6	1	4			8	A Seppi	6	2	5
		O Rochus	0	1					R Gasquet	4	6	7
		R Gasquet	6	6												R Gasquet	6	62	3
	Q	F Cipolla	3	0											2	J Isner	2	7	6
		J Ouanna	6	6					J Ouanna	2	4
								2	J Isner	6	6

References

• Main Draw
• Qualifying Singles