thiopyridone

English

Etymology

thio- +‎ pyridone

Noun

thiopyridone (countable and uncountable, plural thiopyridones)

  1. (organic chemistry) A derivative of a pyridone in which the carbonyl oxygen atom is substituted by one of sulfur
    • 2015 September 26, “C-STrap Sample Preparation Method— In-Situ Cysteinyl Peptide Capture for Bottom-Up Proteomics Analysis in the STrap Format”, in PLOS ONE‎, →DOI:
      Thiopropyl Sepharose™ 6B (GE Healthcare) has been used widely over several decades to reversibly bind biological molecules containing the sulfhydryl groups—the 2-thiopyridyl disulphide group of the sepharose matrix reacts with a molecule containing a free thiol to form a mixed disulfide; during the reaction thiopyridone is formed while the bound target molecule is released by addition of a reducing agent.
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