pyrroloindole

English

Etymology

pyrrolo- +‎ indole

Noun

pyrroloindole (uncountable)

  1. (organic chemistry) A tricyclic aromatic heterocycle composed of a pyrrole ring fused to one of indole
    • 2015 August 5, Patricia Möller-Acuña et al., “Similarities between the Binding Sites of SB-206553 at Serotonin Type 2 and Alpha7 Acetylcholine Nicotinic Receptors: Rationale for Its Polypharmacological Profile”, in PLoS ONE‎, volume 10, →DOI:
      As seen in Fig 8, SB-206553 exhibits a binding mode in the α7 nAChR-ECD where the amino group of the carbamate establishes a hydrogen bond with the carbonyl group of Asp133, whereas the pyrroloindole moiety appears located between Phe151 and Phe155, a position that would favor π-stacking interactions between the corresponding aromatic rings.
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