methotrexate

See also: méthotrexate

English

Chemical structure of methotrexate

Alternative forms

amethopterin

Etymology

Probably from metho- +‎ tre- (“alteration of pteridine”) +‎ (carbo)x(yl)ate.

Pronunciation

(Received Pronunciation) IPA^(key): /ˌmɛθ.əˈtɹɛk.seɪt/, /ˌmiː.θəˈtɹɛk.seɪt/
(General American) IPA^(key): /ˌmɛθ.əˈtɹɛkˌseɪt/

Noun

methotrexate (countable and uncountable, plural methotrexates) (abbreviated MTX)

(pharmacology) An antimetabolite and antifolate drug used in treatment of cancer, autoimmune diseases, and ectopic pregnancies.
- 2010, Siddhartha Mukherjee, The Emperor of All Maladies, Fourth Estate (2011), page 133:
  One group would be treated with intensive methotrexate dosing, while the other group would be treated with milder and less intensive dosing.

Derived terms

-trexate (“folic acid analog”)

Translations

antimetabolite and antifolate drug

French: méthotrexate (fr) m
German: Methotrexat n
Hungarian: metotrexát
Italian: metotrexato m
Kazakh: метотрексат (metotreksat)
Russian: please add this translation if you can
Spanish: metotrexato m

References

“methotrexate”, in Lexico, Dictionary.com; Oxford University Press, 2019–2022.
“methotrexate”, in Merriam-Webster Online Dictionary, Springfield, Mass.: Merriam-Webster, 1996–present.

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