Open Pathology Education Project aims at providing open pathology educational resources for students and educators. This project involves developing, curating and sharing pathology related educational material under CC licenses. Here is the list of topics under the scope of this project. This page contains 87 topic areas.

ImageArticleDescriptionCommons histopathology categoryStructured data item
NeutrophilsMicrograph showing neutrophils in acute inflammation.Category: Neutrophils Neutrophil
Plasma cellsPlasma cell showing eccentrically placed round nucleus with cart wheel like chromatin.Category: Plasma cells Plasma cell
EosinophilsMicrograph showing low power view of Eosinophils.Category: Eosinophils Eosinophil
LymphocyteMicrograph showing lymphocytes in caseating granuloma. Category: LymphocytesLymphocyte
FibroblastsFibroblasts in intestinal pneumonia Category: FibroblastsFibroblast
Foam cellsHistopathology of cholesterolosis of the gallbladder, with annotated foam cell Category: Foam cellFoam cell
MacrophagesLung showing congestion with plenty of alveolar macrophages containing phagocytosed brownish granular hemosiderin pigment. Category: MacrophagesMacrophage
Langhans cellsLanghans giant cell in the centre of a non-caseating granuloma. Category: Langhans giant cellsLanghans giant cell
Foreign body giant cellsMicrograph showing a foreign body engulfed by a giant cell.Category: Foreign body giant cell Foreign body giant cell
Granulation tissueMicrograph showing proliferating capillaries, fibroblasts and acute inflammatory cells. Category: Histopathology of granulation tissueGranulation tissue
Foreign body granulomaGranulomatous reaction to keratin characterized by foreign body giant cells and chronic inflammatory cells.Category: Histopathology of foreign body granuloma Foreign body granuloma, silicone granuloma
Tuberculous granulomaCaseating granulomatous lesion with areas of amorphous granular eosinophilic necrotic debris known as caseation (on the right half) bordered by collections of epitheloid cells, Langhan giant cells and lymphocytes.Category: Histopathology of tuberculous granuloma Tuberculous granuloma
Fat necrosisBreast lump showing an area of fat necrosis showing shadowy outlines of necrotic adipocytes surrounded by an inflammatory reaction with cholesterol clefts.Category: Histopathology of liponecrosis Liponecrosis
Calcinosis cutisMultiple amorphous basophilic calcium deposits in the dermis.Category: Histopathology of calcinosis cutis Calcinosis cutis
Hemochromatosis liverMicrograph of hemochromatosis liver showing hepatocytes with coarse golden yellow granules of hemosiderin within the cytoplasm. These granules stain with Prussian blue stain. Category: Histopathology of hemochromatosishereditary hemochromatosis
Caseous necrosisCaseating granulomatous lesion with areas of amorphous granular eosinophilic necrotic debris known as caseation (on the right half) bordered by collections of epitheloid cells, Langhan giant cells and lymphocytes. Category: Histopathology of caseous necrosiscaseous necrosis
Fatty change in liverHepatic parenchymal cell cytoplasm containing clear vacuoles containing fat of varying sizes, displacing the nucleus towards the periphery.Category: Lipid steatosis steatosis
Carcinoma in situCIN-III (HSIL) showing diffuse severe atypia with loss of maturation involving full thickness of epithelium with intact basement membrane.Category: Histopathology of carcinomas in situCarcinoma in-situ
Lymph node metastasisLymph node showing metastases from colorectal carcinomaCategory: Lymph node metastases Lymph node metastasis
FibroadenomaA well circumscribed lesion showing proliferation of intralobular stroma compressing and distorting the epithelium.Category: Histopathology of breat fibroadenomas Fibroadenoma
Tumor giant cellMalignant neoplasm showing marked anaplasia. Note the marked nuclear pleomorphism, bizarre cells and tumor giant cells.Category: Histopathology of giant cell tumors  Giant cell tumor
Capillary hemangiomaMicrograph showing capillary hemangioma of skin. Category: Histopathology of capillary hemangiomaCapillary hemangioma
Lepromatous leprosySkin biopsy showing epidermal atrophy and multiple dermal infiltrates.Category: Histopathology of leprosy Leprosy
Tuberculoid leprosySkin biopsy showing multiple peri-appendageal granulomas.Category: Histopathology of leprosy Leprosy
Tuberculous lymphadenitisCaseating granulomatous lesion with areas of amorphous granular eosinophilic necrotic debris known as caseation (on the right half) bordered by collections of epitheloid cells, Langhan giant cells and lymphocytes.Category: Histopathology of tuberculous lymphadenitis Tuberculous lymphadentis
Tuberculosis of intestineThe lamina propria is stuffed with wall-to-wall histiocytes. This Kinyoun carbolfuchsin stain shows innumerable acid-fast bacilliCategory: Histopatology of gastrointestinal tuberculosisGastrointestinal tuberculosis
Helminth in appendixMicrograph showing lumen of appendix and cut section of pin worm.Category: Histopathology of appendix with Enterobius vermicularis Parasitic helminthiasis infectious disease
ChromoblastomycosisMicrograph of chromoblastomycosis showing sclerotic bodies in dermis.Category: Histopathology of chromoblastomycosis Chromoblastomycosis
AmoebiasisColonic biopsy showing trophozoite of Entamoeba Histolytica with ingested red blood cells. Category: Histopathology of amoebiasisAmoebiasis
RhinosporidiosisSection of a polyp containing Rhinosporidium seeberiCategory: Histopathology of rhinosporidiosis  Rhinosporidiosis
Filarial lymphadenitisMicrograph showing section of an adult filarial worm. Surrounding tissue shows dense infiltration of eosinophils. Category: Histopathology of filariasesfilariasis
Reactive hyperplasia of lymph nodeHistopathology of a reactive lymph node by the cystic duct in a case of cholecystitis.Category: Reactive hyperplasia of lymph node Reactive hyperplasia
Diffuse B-cell lymphomaLymph node FNA specimen showing diffuse large B cell lymphoma.Category: Histopathology of diffuse large B cell lymphoma  Diffuse large B-cell lymphoma
Follicular lymphomaMicrograph showing a small B-cell lymphoma compatible with follicular lymphoma. H&E stain.Category: Histopathology of follicular lymphomaFollicular lymphoma
Hodgkin's lymphomaMicrograph of a lymph node in Hodgkin's lymphoma with the characteristic Reed-Sternberg cell. RS cell is a large cell with abundant amophophilic cytoplasm and binucleate mirror image nuclei. Each nucleus contains an acidophilic nucleolus surrounded by a halo.Category: Histopathology of Hodgkin's lymphoma   Hodgkin's lymphoma
Congestive hepatopathy (CVC liver)Micrograph showing chronic venous congestion of liverCategory: Histopathology of chronic venous congestion of liver Congestive hepatopathy of liver
Chronic venous congestion of spleenMicrograph showing chronic venous congestion of spleen. Sinusoids are dialated. Organized foci of old hemorrhage seen as areas of fibrosis containing brown pigment (hemosiderin).Category: Histopathology of chronic venous congestion of spleen Chronic venous congestion of spleen
Cavernous hemangiomaHistopathological image reprsenting a cavernous hemangioma of the liver.Category: Histopathology of cavernous liver hemangioma Cavernous hemangioma
AtherosclerosisAtherosclerosis showing extracellular lipid accumulation and foam cells.Category: Histopathology of atherosclerosis Atherosclerosis
EmphysemaMicrograph of empysema lung showing dialated, large alveoli separated by thin septa. Some septae are ruptured and appear to be floating in the alveloar spaces. Grossly emphysematous lung appears pale and voluminous.Category: Histopathology of pulmonary emphysema Emphysema
Squamous cell carcinoma of lungMicrograph of squamous Cell Carcinoma Lung. A lobule of polygonal squamous cells with moderate amount of eosinophilic cytoplasm and hyperchromatic nuclei are seen. The islands show abnormal keratinization in the form of epithelial pearls in the centre. These epithelial pearls are whorls or eddies of malignant cells with pink keratin in the centre.Category: Histopathology of squamous cell carcinoma of the lung Squamous cell carcinoma of lung
Bronchoalveolar carcinomaLepidic pattern of growth of tumor cells along the alveolar wall resembling butterfly sitting on fence. Normal alveoli is seen towards right side.Category: Histopathology of bronchio-alveolar carcinoma Bronchio-alveolar carcinoma
Pulmonary tuberculosisPulmonary tuberculosis characterized by granulomatous inflammation with necrotizing epithelioid granulomas.Category: Histopathology of pulmonary tuberculosis  Pulmonary tuberculosis
AspergillomaThis ectatic bronchus is filled with a colony of Aspergillus. The organisms are confined to the lumen of the bronchus and do not invade surrounding tissues.Category: Histopathology of pulmonary aspergilloma Aspergilloma
Small cell carcinoma of lungMicograph of small Cell Carcinoma Lung. The tumor appears blue because the malignant epithelial cells are small with scanty cytoplasm, nuclei shows finely granulated chromatin. Cells are seen in clusters. There is nuclear overlapping with moulding and crushing.Category: Histopathology of small cell lung cancer Small cell lung cancer
PneumoniaLung tissue showing numerous neutrophils with minimal exudates in the alveolar space with septal wall congestion.Category: Histopathology of pneumonia Lobar pneumonia
Aspiration pneumoniaLung tissue where alveoli contain hemosiderin-laden macrophages and occasional multinucleate giant cells as well as red blood cells.Category: Histopathology of aspiration pneumoniaAspiration pneumonia
Adenocarcinoma colonMicrograph of carcinoma colon showing malignant glands.Nuclei are small and vesicular, located at the bottom of the cell. The cells show increased nucleocytoplasmic ratio.Category: Histopathology of colorectal adenocarcinoma Colorectal carcinoma
Chronic gastric ulcerAcute stress ulcer of stomach in erosive gastritis.Category: Histopathology of gastritis  Gastritis
Adenocarcinoma stomachMicrograph of carcinoma stomach. The glands are seen infiltrating the muscle layer. The neoplastic cells are arranged in cords and in glandular pattern. The cells show dysplastic features. Signet rings with nucleus pushed to the periphery are seen in some types of adenocarcinoma.Category: Histopathology of adenocarcinoma stomach Adenocarcinoma of stomach
Squamous cell carcinoma of the skinWell-differentiated squamous cell carcinoma skin showing malignant cells with mild atypia resembling normal squamous epithelial cells with intercellular bridges, individual cell keratinisation and nests of keratin pearls.Category: Histopathology of squamous cell carcinoma of the skin  Squamous cell carcinoma
Pleomorphic adenomaMicrograph of Pleomorphic Adenoma of Salivary gland. The section shows a cellular area interspersed with islands of lighter stained bluish myxoid tissue. The cellular area is the epithelial element and is composed of cells arranged in sheets and trabeculae. The myxoid areas may resemble cartilage and represent the mesenchymal element.Category: Histopathology of pleomorphic adenoma Pleomorphic adenoma
CirrhosisMicrograph of liver showing nodules of parenchymal liver cells engulfed by broad bands of fibrous tissue. The liver has lost its normal architecture.Category: Histopathology of alcoholic cirrhosis Liver cirrhosis
Fatty liverHepatic parenchymal cell cytoplasm containing clear vacuoles containing fat of varying sizes, displacing the nucleus towards the periphery.Category: Lipid steatosis steatosis
Serous cystadenomaHistopathology of serous cystadenoma, with admixed scattered ciliated cells. This case closely resembles normal surface endometrial epithelium of the uterusCategory: Histopathology of ovarian serous cystadenoma Ovarian cystadenoma
Mucinous cystadenomaMicrograph showing Mucinous Cystadenoma of ovary. The cyst wall is lined by tall columnar epithelium and filled with mucin.Category: Histopathology of mucinous cystadenoma Mucinous cystadenoma
DysgerminomaDysgerminoma characterized by uniform cells resembling primordial germ cells separated by fibrous septa with lymphocytes.Category: Histopathology of ovarian dysgerminoma Ovarian dysgerminoma
Vesicular moleMicrograph of vesicular mole showing oedematous chorionic villus with circumferential proliferation of trophoblasts.Category: Histopathology of chorionic villi chorionic villi
Products of gestationMicrograph showing products of conception. Chorionic villi and decidual tissue are seen.Category: Histopathology of products of conception products of conception
Benign cystic teratomaMicrograph of Teratoma Ovary showing areas of cartilage, mucous glands, squamous epithelium and hair follicle.Category: Histopathology of mature teratoma of ovary teratoma
Seminoma testisMicrograph of seminoma testes showing lobules of uniform cells separated by delicate septae of fibrous tissue. These cells can have a distinct outline with clear cytoplasm. The nuclei are large, with central prominent nucleolus.Category: Histopathology of testicular seminoma  seminoma
EndometriumMicrograph showing proliferative phase of endometrium.Category: Histology of endometrium endometrium
Leiomyoma uterusMicrograph of leiomyoma uterus showing bundles of smooth muscle cells of uniform size and shape. The cells are spindle shaped with oval nucleus.Category: Histopathology of uterine fibroids Leiomyoma
Squamous cell carcinoma of cervixInvasive Squamous Carcinoma of the Cervix. Cold Knife Cone.Category: Histopathology of squamous cell carcinoma of the cervix Invasive squamous carcinoma of cervix
Cystic hyperplasia of endometriumMicrograph showing cystic hyperplasia of endometrium. Cystically dialated glands are lined by proliferative type of epithelium. Stroma also resembles proliferative phase. No atypia is seen in the cells. Category: Histopathology of hyperplasia endometriumCystic hyperplasia
NeuroblastomaHistopathology specimen of neuroblastoma showing Homer Wright rosettes (HE stain)Category: Histopathology of neuroblastoma Neuroblastoma
NephroblastomaAdult Wilm's tumor showing tubular pattern resembling pseudo-rosettes at places. Category: Histopathology of Wilm's tumorWilm's tumor
RetinoblastomaThis retinoblastoma has characteristic Flexner-Wintersteiner rosettes with circular alignment of short columnar cells around a central lumen.Category: Histopathology of retinoblastoma Retinoblastoma
OsteoclastomaThe micrographs show the characteristic giant cells with nuclei that have a similar appearance to the surrounding (mononuclear) cells.Category: Histopathology of giant cell tumor of bone Giant cell tumor
OsteosarcomaSmall cell osteosarcoma, like other osteosarcomas has osteoid, the extracellular organic component of bone. On H&E stained sections, osteoid has a pink, homogeneous appearance and surrounds osteoblasts or osteosarcoma cells. Category: Histopathology of osteosarcomaOsteosarcoma
PlasmacytomaPlasma cell showing eccentrically placed round nucleus with cart wheel like chromatin. Category: Histopathology of plasmacytomaPlasmacytoma
OsteochondromaPerichondrium covering the cartilage cap, which merged into the underlying spongiosa.Category: Histopathology of osteochondroma osteochondroma
Hashimoto's thyroiditisHashimoto's thyroiditis with lymphoid infiltration.Category: Hashimoto's thyroiditis with lymphoid infiltration Hashimoto's thyroiditis
Papillary carcinoma thyroidThe phenomenon of orphan Anne eyes in papillary thyroid cancer.Category: Histopathology of thyroid papillary carcinoma papillary carcinoma
Nodular colloid goitreHistopathology of multinodular toxic goiter, showing normal thyroid follicles with calcification but no psammoma bodies in low magnification and no atypia in higher magnification.Category: Histopathology of goitres goiter
GlioblastomaBiopsy specimen of a Glioblastoma showing extensive cell pleomorphismCategory: Histopathology of glioblastoma glioblastoma
MeningomaConcentrically calcified basophilic structure in the centre of the field in a meningioma.Category: Histopathology of meningoma meningoma
Fibrocystic disease of breastIntermediate magnification micrograph of fibrocystic change of the breast with apocrine metaplasia. Category: Histopathology of fibrocystic breast changesfibrocystic breast
Infiltrative ductal carcinomaAtypical cells with moderate amount of eosinophilic cytoplasm and round to oval dark nucleus with moderate pleomorphism (Papanicolaou, 400X)Category: Histopathology of invasive carcinoma of no special type  invasive breast carcinoma
FibroadenomaA well circumscribed lesion showing proliferation of intralobular stroma compressing and distorting the epithelium.Category: Histopathology of breast fibroadenomas fibroadenoma
Phyllodes tumorPhotomicrograph of a malignant phyllodes tumour. Note stromal cellularity and mitotic figures. Category: Histopathology of cystosarcoma phyllodesPhyllodes tumor
LipomaMicrograph of a lipoma showing fat cells. Category: Histopathology of lipomasLipoma
Basal cell carcinomaSurgical excision biopsy specimen showing histopathology of basal cell carcinoma.Category: Histopathology of basal cell carcinoma Basal cell carcinoma
Malignant melanomaMalignant spindle cell neoplasm, showing numerous mitotic figures, including atypical tripolar mitotic figure, in the centre. Category: Histopathology of melanomaMalignant melanoma
Squamous papillomaMicrograph showing squamous cell papilloma of the tongue.Category: Histopathology of squamous cell carcinoma Squamous papilloma
Renal cell carcinomaMicrograph of clear cell renal cell carcinoma showing cells with clear cytoplasm, typically arranged in nests and nuclear atypia.Category: Histopathology of renal cell carcinoma Renal cell carcinoma
Cresenteric glomerulonephritisPhotomicrograph of the renal biopsy showing prominent fibrocellular crescent formation and moderate mesangial proliferation in a glomerulus.Category: Histopathology of glomerulonephritis glomerulonephritis
Transitional cell carcinomaHistopathology of transitional carcinoma of the urinary bladder.Category: Histopathology of transitional cell carcinoma Urothelial carcinoma

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