Myelofibrosis

Primary myelofibrosis is a relatively rare bone marrow / blood cancer.[1] It is currently classified as a myeloproliferative neoplasm.[2][3]

Signs and symptoms

Symptoms include:

  • Abdominal fullness related to an enlarged spleen (splenomegaly).
  • Bone pain
  • Bruising and easy bleeding due to inadequate numbers of platelets
  • Cachexia (loss of appetite, weight loss, and fatigue)
  • Enlargement of both the liver and spleen
  • Fatigue
  • Gout and high uric acid levels
  • Increased susceptibility to infection, such as pneumonia
  • Pallor and shortness of breath due to anemia
  • In rarer cases, a raised red blood cell volume
  • Cutaneous myelofibrosis is a rare skin condition characterized by dermal and subcutaneous nodules.[4]: 746 

References
  1. "Myelofibrosis Facts" (PDF). The Leukemia and Lymphoma Society. Retrieved 5 October 2014.
  2. myelofibrosis at Dorland's Medical Dictionary
  3. Tefferi, Ayalew (2014). "Primary myelofibrosis: 2014 update on diagnosis, risk-stratification, and management". American Journal of Hematology. 89 (9): 915–925. doi:10.1002/ajh.23703. ISSN 0361-8609. PMID 25124313. S2CID 26059182.
  4. James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 978-0-7216-2921-6.
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