Klinefelter syndrome

Klinefelter syndrome, 47, XXY, or XXY syndrome is a genetic disorder where people have an extra number of X chromosomes.[1] People who have Klinefelter's Syndrome are often called "XXY Males", or "47, XXY Males".[2]

Effects

Males who have this condition are almost always infertile. This means that they cannot father babies.[3]

In other organisms

Any male mammal can have Klinefelter's Syndrome. The mouse is one example.[4] Tortoiseshell or calico markings on male cats are an indicator of Klinefelter's syndrome. These cats are considered to be the model organism for Klinefelter syndrome, because the gene for a cat's orange/black coat markings is found on the X chromosome. [5]

References

Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson (2005). Robbins and Cotran pathologic basis of disease (7th ed.). Philadelphia: Elsevier/Saunders. ISBN 978-0-7216-0187-8.
Bock, Robert (1993). "Understanding Klinefelter Syndrome: A Guide for XXY Males and their Families" (HTML). NIH Pub. No. 93-3202. Office of Research Reporting, NICHD. Retrieved 2007-04-07.
Denschlag, Dominik, MD; Clemens, Tempfer, MD; Kunze, Myriam, MD; Wolff, Gerhard, MD; Keck, Christoph, MD (October 2004). "Assisted reproductive techniques in patients with Klinefelter syndrome: A critical review". Fertility and Sterility. 82 (4): 775–779. doi:10.1016/j.fertnstert.2003.09.085. PMID 15482743.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Russell, Liane Brauch (9 June 1961). "Genetics of Mammalian Sex Chromosomes MOUSE STUDIES THROW LIGHT ON THE FUNCTIONS AND ON THE OCCASIONALLY ABERRANT BEHAVIOR OF SEX CHROMOSOMES". Science. 133 (3467): 1795–1803. doi:10.1126/science.133.3467.1795. PMID 13744853. S2CID 33813090.
Centerwall WR, Benirschke K (1975). "An animal model for the XXY Klinefelter's syndrome in man: Tortoiseshell and calico male cats". American Journal of Veterinary Research. 36 (9): 1275–1280. PMID 1163864.

Other websites

"Klinefelter Syndrome at the Open Directory Project". dmoz.org. Archived from the original on 24 June 2010. Retrieved 27 July 2010.

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[isbn0-7216-0187-1-1] Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson (2005). Robbins and Cotran pathologic basis of disease (7th ed.). Philadelphia: Elsevier/Saunders. ISBN 978-0-7216-0187-8.

[orrnichhd1993full-2] Bock, Robert (1993). "Understanding Klinefelter Syndrome: A Guide for XXY Males and their Families" (HTML). NIH Pub. No. 93-3202. Office of Research Reporting, NICHD. Retrieved 2007-04-07.

[fertstert2004-3] Denschlag, Dominik, MD; Clemens, Tempfer, MD; Kunze, Myriam, MD; Wolff, Gerhard, MD; Keck, Christoph, MD (October 2004). "Assisted reproductive techniques in patients with Klinefelter syndrome: A critical review". Fertility and Sterility. 82 (4): 775–779. doi:10.1016/j.fertnstert.2003.09.085. PMID 15482743.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[Russell-4] Russell, Liane Brauch (9 June 1961). "Genetics of Mammalian Sex Chromosomes MOUSE STUDIES THROW LIGHT ON THE FUNCTIONS AND ON THE OCCASIONALLY ABERRANT BEHAVIOR OF SEX CHROMOSOMES". Science. 133 (3467): 1795–1803. doi:10.1126/science.133.3467.1795. PMID 13744853. S2CID 33813090.

[5] Centerwall WR, Benirschke K (1975). "An animal model for the XXY Klinefelter's syndrome in man: Tortoiseshell and calico male cats". American Journal of Veterinary Research. 36 (9): 1275–1280. PMID 1163864.