Wrigley is an English surname originating in the county of Lancashire.

• Alan Wrigley (born 1931), Australian writer on topics related to intelligence, defence and security
• Ammon Wrigley (1861–1946), English poet and local historian from Saddleworth
• Arthur Wrigley (1912–1965), English cricket scorer and statistician
• Arthur Joseph Wrigley (1902–1983), obstetrician and gynaecologist
• Bernard Wrigley (born 1948), English singer, actor and comedian
• David Wrigley, English general practitioner
• Derek Fuller Wrigley (born 1924), British-born Australian architect
• Drew Wrigley (born 1965), American politician
• E.A. Wrigley (1931-2022), British historical demographer
• Edgar Wrigley (1886−1958), New Zealand rugby union and rugby league player
• George Weston Wrigley (1847–1907), Canadian journalist and social reformer
• Henry Wrigley (1892–1987), Royal Australian Air Force (RAAF) officer
• Hugh Wrigley (1891–1980), Australian Army officer
• Kurt Wrigley (born 1969), Australian rugby league player
• Leslie James Wrigley (1875–1933), Australian academic and educationalist
• Nicholas Wrigley (born 1955), British merchant banker
• Robert Wrigley (born 1951), American poet and educator
• Stephen Wrigley (born 1987), Australian football player
• Sylvia Spruck Wrigley (born 1968), American/German writer of science fiction, fantasy and aviation non-fiction
• Tony Wrigley (born 1931), historical demographer
• Wilf Wrigley (born 1949), English football player
• Zeke Wrigley (1874–1952), baseball player

In the Wm. Wrigley Jr. Company

• William Wrigley, Jr. (1861–1932), founder of the Wm. Wrigley Jr. Company
• Philip K. Wrigley (1894–1977), son of William Wrigley Jr.
• William Wrigley III (1933–99), son of Philip K. Wrigley
• William Wrigley, Jr. II (born 1963), son of William Wrigley III, and chairman

In music

• The Wrigley Sisters (Jennifer and Hazel), folk music duo

Fictional

• Simon 'Bigmac' Wrigley, character in the Johnny Maxwell trilogy by Terry Pratchett