Upper Main Street Historic District may refer to:
- Upper Main Street Historic District (Ansonia, Connecticut)
- Upper Main Street Historic District (Lafayette, Indiana)
- Upper Main Street Historic District (Dubuque, Iowa)
- Upper Main Street Historic District (Hatfield, Massachusetts)
- Upper Main Street Historic District (Menasha, Wisconsin), listed on the National Register of Historic Places in Winnebago County, Wisconsin
See also
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