Route 212 or Highway 212 can refer to:

Canada

• Manitoba Provincial Road 212
• Newfoundland and Labrador Route 212
• Nova Scotia Route 212
• Prince Edward Island Route 212
• Quebec Route 212
• Saskatchewan Highway 212

China

• China National Highway 212

Costa Rica

• National Route 212

India

• National Highway 212

Ireland

• R212 regional road

Japan

• Japan National Route 212

United States

• U.S. Route 212
• Alabama State Route 212
• California State Route 212 (former)
• Florida State Road 212
• Georgia State Route 212
• Iowa Highway 212
• K-212 (Kansas highway)
• Kentucky Route 212
• Maine State Route 212
• Maryland Route 212
• M-212 (Michigan highway)
• Minnesota State Highway 212 (former)
• Montana Secondary Highway 212
• New Mexico State Road 212
• New York State Route 212
• North Carolina Highway 212
• Ohio State Route 212
• Oregon Route 212
• Pennsylvania Route 212
• South Carolina Highway 212
• Tennessee State Route 212
• Texas State Highway 212 (former)
• Utah State Route 212
• Virginia State Route 212
• Wyoming Highway 212

Territories

• Puerto Rico Highway 212