RPL14
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRPL14, CAG-ISL-7, CTG-B33, L14, RL14, hRL14, ribosomal protein L14
External IDsOMIM: 617414 MGI: 1914365 HomoloGene: 68375 GeneCards: RPL14
Orthologs
SpeciesHumanMouse
Entrez

9045

67115

Ensembl

ENSG00000188846

ENSMUSG00000025794

UniProt

P50914

Q9CR57

RefSeq (mRNA)

NM_003973
NM_001034996

NM_025974

RefSeq (protein)

NP_001030168
NP_003964

NP_080250

Location (UCSC)Chr 3: 40.46 – 40.47 MbChr 9: 120.4 – 120.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

60S ribosomal protein L14 is a protein that in humans is encoded by the RPL14 gene.[5][6]

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14E family of ribosomal proteins. It contains a basic region-leucine zipper (bZIP)-like domain. The protein is located in the cytoplasm. This gene contains a trinucleotide (GCT) repeat tract whose length is highly polymorphic; these triplet repeats result in a stretch of alanine residues in the encoded protein. Transcript variants utilizing alternative polyA signals and alternative 5'-terminal exons exist but all encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[6]

Interactions

RPL14 has been shown to interact with PHLDA1.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000188846 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025794 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tanaka M, Tanaka T, Harata M, Suzuki T, Mitsui Y (March 1998). "Triplet repeat-containing ribosomal protein L14 gene in immortalized human endothelial cell line (t-HUE4)". Biochem Biophys Res Commun. 243 (2): 531–7. doi:10.1006/bbrc.1998.8125. PMID 9480843.
  6. 1 2 "Entrez Gene: RPL14 ribosomal protein L14".
  7. Hinz T, Flindt S, Marx A, Janssen O, Kabelitz D (May 2001). "Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product". Cell. Signal. 13 (5): 345–52. doi:10.1016/S0898-6568(01)00141-3. PMID 11369516.

Further reading

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