An outline of the participation of Panamanian football teams in the different regional tournaments offered by the CONCACAF. Since 1988, Panama has been sending at least one team to the competitions, the first appearance by a Panamanian team was in 1988 CONCACAF Champions' Cup when Plaza Amador played in the first round.

The best runs for a Panamanian team in competitions was when in 2002 when Árabe Unido finished runner-up in that year's competition of Copa Interclubes UNCAF.

Teams from Panama have participated in every edition of the CONCACAF Champions League (2008–present). The best results being runs to the quarterfinals on five separate occasions. Arabe Unido (x3: 2010, 2014, and 2017), Tauro FC (2018), and Indepediente (2019).

Panamanian teams have also competed in every edition of the CONCACAF League tournament which began in 2017 and ended in 2021. With four teams reaching the semifinals. Arabe Unido (x2 2017, and 2018), Plaza Amador (2017), and Tauro FC (2018).

Panamanian teams will compete in new CONCACAF Central American Cup which begins in 2023.

CONCACAF Champions Cup era

Season	Team	Round	Opponent	1st Leg	2nd Leg	Aggregate
1988	Plaza Amador	1st Round	Alajuelense	0–2	1–2	1–4
1989	Plaza Amador	1st Round	Coke Milpross	1–1	4–1	5–1
		2nd Round	Pumas UNAM	0–4	0–6	0–10
	Deportivo La Previsora	Preliminary Round	America Managua	1–1	2–0	3–1
		1st Round	Duurly's	3–0	6–2	9–2
		2nd Round	UDG	0–1	5–5	5–6
1990	Tauro FC	1st Round	Firpo	1–1	0–3	1–4
	Deportivo La Previsora	1st Round	Alianza	1–10	0–2	1–12
1991	Plaza Amador	1st Round	Alajuelense	1–4	0–7	1–11
	Tauro FC	1st Round	America Managua	5–0	0–0	5–0
		2nd Round	Saprissa	1–3	0–2	1–5
1992	Eurokickers F.C	1st Round	SF Bay Blackhawks	0–10	0–1	0–11
	Tauro FC	1st Round	Real Esteli	2–0	5–1	7–1
		2nd Round	Dallas Rockets	1–3	2–2	3–5
1993	Sporting Colon	Preliminary Round	Comunicaciones	0–1	1–3	1–4
	Plaza Amador	Preliminary Round	Juventus Managua	5–0	4–0	9–0
		1st Round	Firpo	2–2	0–6	2–8
1995	Árabe Unido	1st Round	FAS	0–4	1–1	1–5
	PROJUSA	1st Round	Juventus Managua	1–1	2–1	3–1
		2nd Round	Guadalajara	0–5	0–10	0–15
1996	Cosmos	1st Round	Comunicaciones	0–2	0–4	0–6
	Árabe Unido	1st Round	Real Esteli	1–1	1–0	2–1
		2nd Round	Victoria	0–1	1–2	1–3
1997	Eurokickers F.C	Preliminary Round	Dariangen FC	4–2	1–4	5–6
	Tauro FC	1st Round	CS Cartagines	0–5	2–4	2–9

CONCACAF Champions League era (2008–present)

Season	Team	Round	Opponent	Home	Away	Aggregate
2008–09	San Francisco	Preliminary Round	Jalapa	5–0	0–1	5–1
		Group Stage	Pumas UNAM	1–1	0–6	4th
			Houston Dynamo	0–0	1–2
			Firpo	2–3	0–1
	Tauro FC	Preliminary Round	Chivas USA	2–0	1–1	3–1
		Group Stage	Puerto Rico Islanders	2–2	1–2	3rd
			Municipal	2–1	2–2
			Santos Laguna	2–0	0–3
2009–10	San Francisco	Preliminary Round	San Juan Jabloteh	2–0	0–3	2–3
	Arabe Unido	Preliminary Round	Olimpia	1–0	1–2	2–2 (a)
		Group Stage	Pachuca	4–1	0–2	2nd
			Houston Dynamo	1–1	1–5
			Isidro Metapán	6–0	1–0
		Quarterfinals	Cruz Azul	0–1	0–3	0–4
2010–11	Tauro FC	Preliminary Round	Marathón	0–3	2–1	2–4
	San Francisco	Preliminary Round	Cruz Azul	2–3	0–6	2–9
	Arabe Unido	Group Stage	Real Salt Lake	2–3	1–2	4th
			Toronto FC	1–0	0–1
			Cruz Azul	0–6	0–2
2011–12	San Francisco	Preliminary Round	Seattle Sounders	1–0	0–2	1–2
	Tauro FC	Group Stage	Toronto FC	1–2	0–1	4th
			Pumas UNAM	0–0	0–1
			FC Dallas	5–3	1–1
2012–13	Tauro FC	Group Stage	Real Salt Lake	0–1	0–2	3rd
			Herediano	0–1	1–2
	Chorrillo	Group Stage	Monterrey	0–6	0–5	3rd
			Municipal	1–2	1–2
Season	Team	Round	Opponent	Home	Away	Aggregate
2013–14	Sporting San Miguelito	Group Stage	Club América	0–1	0–3	3rd
			Alajuelense	1–0	0–2
	Arabe Unido	Group Stage	W Connection	3–1	2–0	1st
			Houston Dynamo	1–0	1–2
		Quarterfinals	Alajuelense	0–2	0–0	0–2
2014–15	Tauro FC	Group Stage	Waterhouse	1–2	1–4	3rd
			D.C. United	0–1	0–2
	Chorrillo	Group Stage	Cruz Azul	1–0	0–3	3rd
			Alajuelense	1–1	0–1
2015–16	San Francisco	Group Stage	Querétaro	2–1	0–2	2nd
			Verdes	8–0	1–2
	Arabe Unido	Group Stage	Montego Bay United	3–0	2–1	2nd
			D.C. United	0–1	0–2
2016–17	Plaza Amador	Group Stage	Herediano	1–1	0–2	3rd
			Tigres UANL	1–0	1–3
	Arabe Unido	Group Stage	Monterrey	2–1	3–2	1st
			Don Bosco	2–0	5–2
		Quarterfinals	FC Dallas	2–1	0–4	2–5
2018	Tauro FC	Round of 16	FC Dallas	1–0	2–3	3–3 (a)
		Quarterfinals	Club América	1–3	0–4	1–7
2019	Independiente	Round of 16	Toronto FC	4–0	1–1	5–1
		Quarterfinals	Sporting Kansas City	2–1	0–3	2–4

CONCACAF League (2017–2021)

Season	Team	Round	Opponent	Home	Away	Aggregate
2017	Chorrillo	Round of 16	Honduras Progresso	1–0	1–0	2–0
		Quarterfinals	Santos de Guápiles	0–1	1–0	0–2
	Plaza Amador	Round of 16	Portmore United	1–0	0–1	1–1 (5–4 p)
		Quarterfinals	Walter Ferreti	2–1	0–0	2–1
		Semifinals	Olimpia	1–7	1–1	2–8
	Árabe Unido	Round of 16	Central	3–0	2–1	5–1
		Quarterfinals	Águila	0–1	2–0	2–1
		Semifinals	Santos de Guápiles	0–0	0–1	0–1
2018	Universitario	Round of 16	Diriangén	3–1	4–0	7–1
		Quarterfinals	Herediano	1–2	0–3	1–4
	Tauro	Round of 16	Real España	1–0	1–1	2–1
		Quarterfinals	Walter Ferreti	3–1	4–0	7–1
		Semifinals	Motagua	2–1	0–2	2–3
	Árabe Unido	Round of 16	Arnett Gardens	3–0	1–2	4–2
		Quarterfinals	FAS	3–1	1–0	4–1
		Semifinals	Herediano	1–0	0–2	1–2
2019	Tauro	Round of 16	Alianza	1–0	0–2	1–2
	Independiente	Round of 16	S.V. Robinhood	2–1	1–1	3–2
		Quarterfinals	Saprissa	0–0	0–0	0–0
	San Francisco	Preliminary Round	Alianza	0–1	1–5	1–6
2020	Tauro	Round of 16	Forge FC	1–2	N/A
	Independiente	Preliminary Round	Antigua GFC	0–0 (2–4 p)	N/A
	San Francisco	Round of 16	Alajuelense	0–1	N/A
2021	Independiente	Round of 16	Forge FC	0–2	0–0	0–2
	Plaza Amador	Round of 16	Santos de Guápiles	0–2	0–1	0–3
	Universitario	Preliminary round	Samaritaine	N/A		3–0 (w/o)
		Round of 16	Motagua	2–2	0–1	2–3