SLCO1A2
Identifiers
AliasesSLCO1A2, OATP, OATP-A, OATP1A2, SLC21A3, solute carrier organic anion transporter family member 1A2
External IDsOMIM: 602883 MGI: 1351865 HomoloGene: 56603 GeneCards: SLCO1A2
Orthologs
SpeciesHumanMouse
Entrez

6579

108096

Ensembl

ENSG00000084453

ENSMUSG00000063975

UniProt

P46721

Q91YY5

RefSeq (mRNA)

NM_005075
NM_021094
NM_134431

NM_001267707
NM_130861

RefSeq (protein)

NP_066580
NP_602307

NP_001254636
NP_570931

Location (UCSC)Chr 12: 21.26 – 21.42 MbChr 6: 142.18 – 142.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene.[5][6]

This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternate splicing of this gene results in three transcript variants encoding two different isoforms.[6]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000084453 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000063975 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kullak-Ublick GA, Beuers U, Meier PJ, Domdey H, Paumgartner G (Apr 1997). "Assignment of the human organic anion transporting polypeptide (OATP) gene to chromosome 12p12 by fluorescence in situ hybridization". J Hepatol. 25 (6): 985–7. doi:10.1016/S0168-8278(96)80307-2. PMID 9007731.
  6. 1 2 "Entrez Gene: SLCO1A2 solute carrier organic anion transporter family, member 1A2".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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