Manuel Dominguez (1803–1882) was a Californian rancher.
Manuel Domínguez may also refer to:
- Manuel Domínguez (1868–1935), Vice President of Paraguay from 1902 to 1904
- Manuel Domínguez (early 20th century), Paraguayan writer and member of Viriato Díaz Pérez's 1907 literary circle La Colmena
- Manuel Jorge Domínguez (born 1962), Spanish cyclist
- Manuel Domínguez González (born 1974), Spanish politician
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