Mahfouz is a surname. Notable people with the name include:
- Khalid bin Mahfouz (1949–2009), Saudi businessman
- Naguib Mahfouz, Nobel Prize–winning Egyptian novelist
- Naguib Pasha Mahfouz (1882–1974), Egyptian obstetrician and gynecologist
- Sabir Mahfouz Lahmar, Algerian-born naturalised Bosnian citizen detained by the United States in Guantanamo Bay, Cuba from 2002 to 2009
See also
- Mahfuz, a given name
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