Route 515, or Highway 515, may refer to:

Afghanistan

• Route 515 (Afghanistan) in Farah Province

Canada

• Alberta Highway 515
• New Brunswick Route 515
• Ontario Highway 515 (former)

India

• National Highway 515 (India)

United Kingdom

• A515 road

United States

• Interstate 515 (concurrent with U.S. routes 93 and 95)
• Lake County, California County Route 515
• Brevard, Florida County Route 515
• Georgia State Route 515
• Maryland Route 515
• County Route 515 (New Jersey)
• North Carolina Highway 515 (former)
• Ohio State Route 515
• Pennsylvania Route 515 (former)
• Virginia State Route 515 (former)
• Washington State Route 515

Territories

• Puerto Rico Highway 515