The following highways are numbered 381:
Brazil
Canada
Japan
United States
Interstate 381
Georgia State Route 381 (former)
Kentucky Route 381
Maryland Route 381
New York State Route 381 (former)
North Carolina Highway 381
Pennsylvania Route 381
Puerto Rico Highway 381
South Carolina Highway 381
Tennessee State Route 381
Virginia State Route 381
| Preceded by 380 |
Lists of highways 381 |
Succeeded by 382 |
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