People with the surname
- Henry C. Karpen (1868–1936), American politician
- Judy Karpen (born 1953), American astrophysicist
- Nicolae Vasilescu-Karpen (1870–1964), Romanian engineer and physicist
- Richard Karpen (born 1957), American electronic music composer
Other
- Anton and Mary Agnes Karpen House, a historic building in South Dakota
- Karpen House, a historic building in New York
- S. Karpen & Bros., American furniture manufacturer
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