Juan Guzmán may refer to:

Sportspeople

• Juan Guzmán (baseball) (born 1966), former pitcher in Major League Baseball, primarily with the Toronto Blue Jays
• Juan Pablo Guzmán (born 1981), Argentinian professional tennis player
• Juan Reynoso Guzmán (born 1969), Peruvian retired football defender
• Juan Guzman (soccer) (born 1988), American soccer player
• Juan Guzman (boxer) (1951-2021), Dominican Republic boxer

Politicians

• Juan José Guzmán (1797–1847), President of El Salvador, 1842–1844
• Juan de Guzmán (died 1569), post-Conquest tlatoani (ruler) of the state of Coyoacan in the Valley of Mexico

Others

• Juan Guzmán (archbishop) (1572–1634), Spanish Roman Catholic archbishop
• Juan Guzmán (patriarch) (died 1605), Spanish Roman Catholic patriarch
• Juan Guzmán Tapia (1939–2021), Chilean judge
• Juan Guzmán (photographer) (1911–1982), German born Mexican photographer

See also

• Joan Guzmán (born 1976), flyweight boxer