Issam is an Arabic name. Notable people with the name include:
- Issam (born 1993), Moroccan rapper
- Issam Alnajjar (born 2003), Jordanian musician and actor
- Issam Chebake (born 1989), Moroccan footballer
- Issam Fares (born 1937), Lebanese businessman and politician
- Issam Hajali, Lebanese musician
- Issam Abu Jamra (born 1937), Lebanese military officer and politician
- Issam Jebali (born 1991), Tunisian footballer
- Issam Jellali (born 1981), Tunisian tennis player
- Issam Sartawi (1935–1983), Palestinian cardiologist and politician
- Issam Zahreddine (1961–2017), Syrian military officer
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