Interstate 80 (I-80) is a transcontinental Interstate Highway in the United States, stretching from San Francisco, California, to Teaneck, New Jersey. In Indiana, it consists entirely of the following two highways:

• The Borman Expressway, from the Illinois state line to Lake Station, Indiana, running concurrently with I-94, U.S. Highway 6 (US 6), and a small portion of US 41.
• The Indiana Toll Road, from Lake Station to the Ohio state line, running concurrently with I-90. It comprises over 85% of the whole route.