ITSN1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesITSN1, ITSN, SH3D1A, SH3P17, intersectin 1
External IDsOMIM: 602442 MGI: 1338069 HomoloGene: 2277 GeneCards: ITSN1
Orthologs
SpeciesHumanMouse
Entrez

6453

16443

Ensembl

ENSG00000205726

ENSMUSG00000022957

UniProt

Q15811
Q6J334

Q9Z0R4

RefSeq (mRNA)

NM_001110275
NM_001110276
NM_010587

RefSeq (protein)

NP_001103745
NP_001103746
NP_034717

Location (UCSC)Chr 21: 33.64 – 33.9 MbChr 16: 91.53 – 91.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Intersectin-1 is a protein that, in humans, is encoded by the ITSN1 gene.[5][6]

Function

The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far.[7]

Interactions

ITSN1 has been shown to interact with:

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000205726 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022957 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Guipponi M, Scott HS, Chen H, Schebesta A, Rossier C, Antonarakis SE (Nov 1998). "Two isoforms of a human intersectin (ITSN) protein are produced by brain-specific alternative splicing in a stop codon". Genomics. 53 (3): 369–76. doi:10.1006/geno.1998.5521. PMID 9799604.
  6. Yamabhai M, Hoffman NG, Hardison NL, McPherson PS, Castagnoli L, Cesareni G, Kay BK (Nov 1998). "Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains". The Journal of Biological Chemistry. 273 (47): 31401–7. doi:10.1074/jbc.273.47.31401. PMID 9813051.
  7. "Entrez Gene: ITSN1 intersectin 1 (SH3 domain protein)".
  8. Hussain NK, Jenna S, Glogauer M, Quinn CC, Wasiak S, Guipponi M, Antonarakis SE, Kay BK, Stossel TP, Lamarche-Vane N, McPherson PS (Oct 2001). "Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP". Nature Cell Biology. 3 (10): 927–32. doi:10.1038/ncb1001-927. PMID 11584276. S2CID 22914248.
  9. Snyder JT, Worthylake DK, Rossman KL, Betts L, Pruitt WM, Siderovski DP, Der CJ, Sondek J (Jun 2002). "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors". Nature Structural Biology. 9 (6): 468–75. doi:10.1038/nsb796. PMID 12006984. S2CID 13161854.
  10. Fernández-Chacón R, Achiriloaie M, Janz R, Albanesi JP, Südhof TC (Apr 2000). "SCAMP1 function in endocytosis". The Journal of Biological Chemistry. 275 (17): 12752–6. doi:10.1074/jbc.275.17.12752. PMID 10777571.
  11. Okamoto M, Schoch S, Südhof TC (Jun 1999). "EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis?". The Journal of Biological Chemistry. 274 (26): 18446–54. doi:10.1074/jbc.274.26.18446. PMID 10373452.
  12. Tong XK, Hussain NK, de Heuvel E, Kurakin A, Abi-Jaoude E, Quinn CC, Olson MF, Marais R, Baranes D, Kay BK, McPherson PS (Mar 2000). "The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain". The EMBO Journal. 19 (6): 1263–71. doi:10.1093/emboj/19.6.1263. PMC 305667. PMID 10716926.

Further reading

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