EXOSC2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEXOSC2, RRP4, Rrp4p, hRrp4p, p7, Exosome component 2, SHRF
External IDsOMIM: 602238 MGI: 2385133 HomoloGene: 6095 GeneCards: EXOSC2
Orthologs
SpeciesHumanMouse
Entrez

23404

227715

Ensembl

ENSG00000130713

ENSMUSG00000039356

UniProt

Q13868

Q8VBV3

RefSeq (mRNA)

NM_001282708
NM_001282709
NM_014285

NM_144886

RefSeq (protein)

NP_001269637
NP_001269638
NP_055100

NP_659135

Location (UCSC)Chr 9: 130.69 – 130.71 MbChr 2: 31.56 – 31.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Exosome component 2, also known as EXOSC2, is a protein which in humans is encoded by the EXOSC2 gene.[5][6]

Function

Mammalian mRNAs contain AU-rich elements (AREs) within their three prime untranslated regions. In yeast, 3-prime-to-5-prime mRNA degradation is mediated by the exosome, a multisubunit particle. EXOSC2 (which is homologous to the yeast Rrp4 protein) is a component of the human exosome.[7]

Interactions

Exosome component 2 has been shown to interact with:

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000130713 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039356 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: EXOSC2 exosome component 2".
  6. Mitchell P, Petfalski E, Shevchenko A, Mann M, Tollervey D (November 1997). "The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases". Cell. 91 (4): 457–66. doi:10.1016/S0092-8674(00)80432-8. PMID 9390555. S2CID 16035676.
  7. Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M (November 2001). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186. S2CID 14817671.
  8. 1 2 Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (Nov 2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/s0022-2836(02)00947-6. PMID 12419256.

Further reading


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