In enzymology, a cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) is an enzyme that catalyzes the chemical reaction

cinnamyl alcohol + NADP⁺ ${\displaystyle \rightleftharpoons }$ cinnamaldehyde + NADPH + H⁺

Thus, the two substrates of this enzyme are cinnamyl alcohol and NADP⁺, whereas its 3 products are cinnamaldehyde, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is cinnamyl-alcohol:NADP⁺ oxidoreductase. Other names in common use include cinnamyl alcohol dehydrogenase, and CAD. This enzyme participates in phenylpropanoid biosynthesis.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1YQD, 1YQX, 2CF5, and 2CF6.

References

• Sarni F, Grand C, Boudet AM (1984). "Purification and properties of cinnamoyl-CoA reductase and cinnamyl alcohol dehydrogenase from poplar stems (Populus X euramericana)". Eur. J. Biochem. 139 (2): 259–65. doi:10.1111/j.1432-1033.1984.tb08002.x. PMID 6365550.
• Wyrambik D, Grisebach H (1975). "Purification and properties of isoenzymes of cinnamyl-alcohol dehydrogenase from soybean-cell-suspension cultures". Eur. J. Biochem. 59 (1): 9–15. doi:10.1111/j.1432-1033.1975.tb02418.x. PMID 1250.
• Wyrambik D, Grisebach H (1979). "Enzymic synthesis of lignin precursors. Further studies on cinnamyl-alcohol dehydrogenase from soybean-cell-suspension cultures". Eur. J. Biochem. 97 (2): 503–9. doi:10.1111/j.1432-1033.1979.tb13138.x. PMID 572771.