Challis is a surname. Notable people with the surname include:
- Alva Challis (1930–2010), Welsh-born New Zealand geologist
- Christopher Challis (1919–2012), British cinematographer
- Ellie Challis (born 2004), British Paralympic swimmer
- George Challis (rugby league), Australian rugby player
- Gordon Challis (1932–2018), New Zealand poet
- James Challis, British clergyman and astronomer
- John Challis (1942–2021), English actor
- John Henry Challis, Anglo-Australian merchant and philanthropist
See also
- Chalis, surname
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