CYTL1
Identifiers
AliasesCYTL1, C17, C4orf4, cytokine like 1
External IDsOMIM: 607930 MGI: 2684993 HomoloGene: 10254 GeneCards: CYTL1
Orthologs
SpeciesHumanMouse
Entrez

54360

231162

Ensembl

ENSG00000170891

ENSMUSG00000062329

UniProt

Q9NRR1

A1E5L0

RefSeq (mRNA)

NM_018659

NM_001081106

RefSeq (protein)

NP_061129

NP_001074575

Location (UCSC)Chr 4: 5.01 – 5.02 MbChr 5: 37.89 – 37.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cytokine-like protein 1 (also protein C17) is a protein that in humans is encoded by the CYTL1 gene.[5]

Function

Protein C17 is a cytokine-like protein specifically expressed in bone marrow and cord blood mononuclear cells that bear the CD34 surface marker.[6] Functionally, C17 was identified as a secretory protein expressed in CD34+ haemopoietic cells.[6] CYTL1 seems to regulate chondrogenesis and is required for the maintenance of cartilage homeostasis and might, additionally, work as a regulatory factor in embryo implantation in the stage of early pregnancy.[7]

This family of proteins, C17, is found in vertebrates. Proteins have two conserved sequence motifs: PPTCYSR and DDC.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000170891 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000062329 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Cytokine-like 1".
  6. 1 2 Liu X, Rapp N, Deans R, Cheng L (May 2000). "Molecular cloning and chromosomal mapping of a candidate cytokine gene selectively expressed in human CD34+ cells". Genomics. 65 (3): 283–92. doi:10.1006/geno.2000.6170. PMID 10857752.
  7. Ai Z, Jing W, Fang L (2016). "Cytokine-Like Protein 1(Cytl1): A Potential Molecular Mediator in Embryo Implantation". PLOS ONE. 11 (1): e0147424. Bibcode:2016PLoSO..1147424A. doi:10.1371/journal.pone.0147424. PMC 4723121. PMID 26800213.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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