CYB5A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCYB5A, CYB5, MCB5, Cytochrome b5, type A, cytochrome b5 type A, METAG
External IDsOMIM: 613218 MGI: 1926952 HomoloGene: 41475 GeneCards: CYB5A
Orthologs
SpeciesHumanMouse
Entrez

1528

109672

Ensembl

ENSG00000166347

ENSMUSG00000024646

UniProt

P00167

P56395

RefSeq (mRNA)

NM_001190807
NM_001914
NM_148923

NM_025797
NM_001348159

RefSeq (protein)

NP_001177736
NP_001905
NP_683725

NP_080073
NP_001335088

Location (UCSC)Chr 18: 74.25 – 74.29 MbChr 18: 84.86 – 84.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cytochrome b5, form A (gene name CYB5A), is a human microsomal cytochrome b5.[5]

Cytochrome b5 is a membrane bound hemoprotein which functions as an electron carrier for several membrane bound oxygenases. It has two isoforms produced by alternative splicing. Isoform 1 is bound to the cytoplasmic side of the endoplasmic reticulum. It has a C-terminal transmembrane alpha-helix. Isoform 2 was found in cytoplasm. Defects in CYB5A are the cause of type IV hereditary methemoglobinemia.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000166347 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024646 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: CYB5A Cytochrome b5, form A".

Further reading


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