COL25A1
Identifiers
AliasesCOL25A1, AMY, CLAC, CLAC-P, CLACP, CFEOM5, Collagen, type XXV, alpha 1, collagen type XXV alpha 1, collagen type XXV alpha 1 chain
External IDsOMIM: 610004 MGI: 1924268 HomoloGene: 57111 GeneCards: COL25A1
Orthologs
SpeciesHumanMouse
Entrez

84570

77018

Ensembl

ENSG00000188517

ENSMUSG00000058897

UniProt

Q9BXS0

Q99MQ5

RefSeq (mRNA)

NM_001256074
NM_032518
NM_198721

NM_001244952
NM_029838
NM_198711

RefSeq (protein)

NP_001243003
NP_115907
NP_942014

NP_001231881
NP_084114
NP_942004

Location (UCSC)Chr 4: 108.81 – 109.3 MbChr 3: 129.93 – 130.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Collagen alpha-1(XXV) chain is a protein that in humans is encoded by the COL25A1 gene.[5][6]

COL25A1 is a brain-specific membrane-bound collagen. Proteolytic processing releases CLAC, a soluble form of COL25A1 containing the extracellular collagen domains that associates with senile plaques in Alzheimer disease (AD; MIM 104300) brains (Osada et al., 2005).[supplied by OMIM][6]

Interactions

Collagen, type XXV, alpha 1 has been shown to interact with Amyloid precursor protein.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000188517 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000058897 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Hashimoto T, Wakabayashi T, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DM, Iwatsubo T (Apr 2002). "CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV". EMBO J. 21 (7): 1524–34. doi:10.1093/emboj/21.7.1524. PMC 125364. PMID 11927537.
  6. 1 2 "Entrez Gene: COL25A1 collagen, type XXV, alpha 1".

Further reading


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