CEBPE
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCEBPE, C/EBP-epsilon, CRP1, CCAAT/enhancer binding protein epsilon, CCAAT enhancer binding protein epsilon, c/EBP epsilon
External IDsOMIM: 600749 MGI: 103572 HomoloGene: 1367 GeneCards: CEBPE
Orthologs
SpeciesHumanMouse
Entrez

1053

110794

Ensembl

ENSG00000092067

ENSMUSG00000052435

UniProt

Q15744

Q6PZD9

RefSeq (mRNA)

NM_001805

NM_207131

RefSeq (protein)

NP_001796

NP_997014

Location (UCSC)Chr 14: 23.12 – 23.12 MbChr 14: 54.95 – 54.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CCAAT/enhancer binding protein (C/EBP), epsilon, also known as CEBPE and CRP1, is a type of ccaat-enhancer-binding protein. CEBPE is its human gene[5][6] and is pro-apoptotic.[7]

The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-δ. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with specific granule deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000092067 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052435 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon".
  6. Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG (Jul 1996). "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus". Genomics. 35 (1): 30–8. doi:10.1006/geno.1996.0319. PMID 8661101.
  7. Nakajima H, Watanabe N, Shibata F, Kitamura T, Ikeda Y, Handa M (May 2006). "N-terminal region of CCAAT/enhancer-binding protein epsilon is critical for cell cycle arrest, apoptosis, and functional maturation during myeloid differentiation". The Journal of Biological Chemistry. 281 (20): 14494–502. doi:10.1074/jbc.M600575200. PMID 16531405.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.