beta-lysine 5,6-aminomutase
Identifiers
EC no.5.4.3.3
CAS no.9075-69-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a beta-lysine 5,6-aminomutase (EC 5.4.3.3) is an enzyme that catalyzes the chemical reaction

(3S)-3,6-diaminohexanoate (3S,5S)-3,5-diaminohexanoate

Hence, this enzyme has one substrate, (3S)-3,6-diaminohexanoate, and one product, (3S,5S)-3,5-diaminohexanoate.

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring amino groups. The systematic name of this enzyme class is (3S)-3,6-diaminohexanoate 5,6-aminomutase. Other names in common use include beta-lysine mutase, and L-beta-lysine 5,6-aminomutase. This enzyme participates in lysine degradation. It employs one cofactor, cobamide.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1XRS.

References

    • Retey J, Kunz F, Arigoni D, Stadtman TC (1978). "Zur Kenntnis der beta-Lysin-Mutase-Reaktion: mechanismus und sterischer Verlauf". Helv. Chim. Acta. 61 (8): 2989–2998. doi:10.1002/hlca.19780610824.
    • Stadtman TC, Renz P (1968). "Anaerobic degradation of lysine. V. Some properties of the cobamide coenzyme-dependent beta-lysine mutase of Clostridium sticklandii". Arch. Biochem. Biophys. 125 (1): 226–39. doi:10.1016/0003-9861(68)90657-7. PMID 5649516.


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