Artists and musicians

• Aldo Sambrell (1931–2010), Spanish actor also known as Alfredo Sanchez Brell
• Alfredo Armas Alfonzo (1921–1990), Venezuelan writer
• Alfredo Bryce (born 1939), Peruvian writer
• Alfredo Cardona Peña (1917–1995), Costa Rican journalist, writer, biographer, poet, and essayist
• Alfredo Casella (1883–1947), Italian composer, pianist and conductor
• Alfredo Casero (born 1962), Argentine musician, actor and comedian
• Alfredo Castro (born 1955), Chilean actor
• Alfredo Catalani (1854–1893), Italian operatic composer
• Alfredo Filippini (1924–2020), Italian sculptor, painter and illustrator
• Alfredo Gil (1915–1999), Mexican singer
• Alfredo Kraus (1927–1999), Spanish operatic tenor
• Alfred Molina (born 1953), English-American actor born Alfredo Molina
• Al Pacino (born 1940), American actor

Politicians

• Albee Benitez (born 1966), Filipino-American businessman and politician
• Alfredo Baldomir (1884–1948), President of Uruguay, soldier and architect
• Alfredo Baquerizo (1859–1951), President of Ecuador
• Alfredo Cachia Zammit (1890–1960), Maltese philanthropist and politician
• Alfredo Caruana Gatto (1868–1926), Maltese lawyer, politician and naturalist
• Alfredo Cristiani (born 1947), President of El Salvador
• Alfredo del Mazo Maza (born 1975), Mexican politician
• Alfredo Junqueira Dala, Angolan politician
• Alfredo Lim (1929–2020), Chinese-Filipino politician and former mayor of the city of Manila
• Alfredo Moreno Charme (born 1956), Chilean diplomat and politician
• Alfredo Moreno Echeverría (born 1988), Chilean politician
• Alfredo Ovando Candía (1918–1982), Bolivian president
• Alfredo Palacio (born 1939), President of Ecuador (2005–2007)
• Alfredo Palacios (1880–1965), Argentine politician
• Alfredo Oscar Saint-Jean (1926–1987), acting President of Argentina
• Alfredo Sirkis (1950–2020), Brazilian politician and writer
• Alfredo Stroessner (1912–2006), President of Paraguay
• Alfredo Zayas y Alfonso (1861–1934), President of Cuba

Sportsmen

• Alfredo (born 1946), Brazilian footballer born as Alfredo Mostarda Filho
• Alfredo II (1920–1997), Brazilian footballer born as Alfredo Ramos dos Santos
• Alfredo Ábalos (born 1986), Argentine footballer
• Alfredo Aceves (born 1982), Mexican baseball player
• Alfredo Aglietti (born 1970), Italian footballer and manager
• Alfredo Aguilar (born 1988), Paraguayan goaltender
• Alfredo Álvarez Calderón (1918–2001), Peruvian diver
• Alfredo Amézaga (born 1978), Mexican baseball player
• Alfredo Anderson (born 1978), Panamanian footballer
• Alfredo Bifulco (born 1997), Italian footballer
• Alfredo Binda (1902–1986), Italian world champion cyclist
• Alfredo Bogarín (born 1936), Paraguayan fencer
• Alfredo Bóia (born 1975), Portuguese footballer
• Alfredo Brilhante da Costa (1904–1980), Brazilian footballer
• Al Cabrera (1881–1964), Spanish baseball player born Alfredo Cabrera
• Alfredo Calderón (1918–2001), Peruvian diver
• Alfredo Cariello (born 1979), Italian footballer
• Alfredo Carmona (born 1971), Peruvian footballer
• Alfredo Carrillo (born 1976), Paraguayan swimmer
• Alfredo Castro (born 1962), Portuguese goalkeeper
• Alfredo Challenger (born 1979), Caymanian footballer
• Alfredo del Águila (1935–2018), Mexican footballer
• Alfredo Devincenzi (1907–?), Italian-Argentine footballer
• Alfredo Di Stéfano (1926–2014), Argentine footballer and coach
• Alfredo Donnarumma (born 1990), Italian footballer
• Alfredo Esteves (born 1976), Portuguese-East Timorese footballer and manager
• Alfredo Fígaro (born 1984), Dominican baseball pitcher
• Alfredo Foni (1911–1985), Italian footballer and coach
• Alfredo Francisco Martins (1992), Brazilian footballer
• Alfredo Frausto (born 1983), Mexican footballer
• Alfredo González Tahuilán (born 1980), Mexican footballer
• Alfredo Griffin (born 1957), Dominican baseball player and coach
• Alfredo Guzmán (born 1943), Mexican swimmer
• Alfredo Jesus da Silva, Portuguese footballer
• Alfredo Lucero (born 1979), Argentine cyclist
• Alfredo Marte (born 1989), Dominican baseball player
• Alfredo Mazacotte (born 1987), Paraguayan footballer
• Alfredo Mejía (born 1990), Honduran footballer
• Alfredo Mendoza (born 1963), Paraguayan footballer
• Alfredo Morales (born 1990), German footballer
• Alfredo Morelos (born 1996), Colombian footballer
• Alfredo Moreno (1980–2021), Argentine footballer
• Alfredo Moreno Caño (born 1981), Spanish track cyclist
• Alfredo Mostarda Filho (born 1946), Brazilian footballer
• Alfredo Omar Tena (born 1985), Mexican footballer
• Alfredo Ortuño (born 1991), Spanish footballer
• Alfredo Pacheco (1982–2015), Salvadoran footballer
• Alfredo Padilla (born 1989), Colombian footballer
• Alfredo Pedraza (born 2000), Spanish footballer
• Al Pedrique (born 1960), Venezuelan baseball player and coach born Alfredo José Pedrique Garcia
• Alfredo Pereira (born 1992), Portuguese acrobatic gymnast
• Alfredo Pérez (born 1952), Venezuelan boxer
• Alfredo Pián (1912–1990), Argentinian racing driver
• Alfredo Pussetto (born 1994), Argentine footballer
• Alfredo Quesada (born 1949), Peruvian footballer
• Alfredo Quintana (1988–2021), Portuguese handballer
• Alfredo Ramírez (born 1988), Argentine footballer
• Alfredo Ramos (1924–2012), Brazilian footballer
• Alfredo Ramúa (born 1986), Argentine footballer
• Alfredo Roberts (born 1965), American football player and coach
• Alfredo Rojas (born 1937), Argentine footballer
• Alfredo Rojas (born 1991), Peruvian footballer
• Alfredo Saldívar (born 1990), Mexican goalkeeper
• Alfredo Santaelena (born 1967), Spanish footballer
• Alfredo dos Santos (1920–1997), Brazilian footballer
• Alfredo Shahanga (born 1965), Tanzanian long-distance runner
• Alfredo Simón (born 1981), Dominican baseball pitcher
• Alfredo Stephens (born 1994), Panamanian footballer
• Alfredo Talavera (born 1982), Mexican goalkeeper
• Alfredo Tena (born 1956), Mexican footballer
• Alfredo Alves Tinoco (1904–1975), Brazilian footballer
• Alfredo Torres (born 1931), Mexican footballer
• Alfredo Valente (born 1980), Canadian soccer player
• Alfredo Valentini (born 1946), Sammarinese sports shooter
• Alfredo Virginio Cano (born 1982), Argentine footballer
• Babù (born 1980), Brazilian footballer born as Alfredo Manzano Gutierrez
• Fredy (born 1990), Angolan footballer born as Alfredo Kulembe Ribeiro
• Freddy Gonzalez (born 1978), Filipino footballer born as Alfredo Fernando Razón Gonzalez
• Marcão (born 1986), Brazilian footballer born as Alfredo Marcos da Silva Junior
• Máyor (born 1984), Spanish footballer born as Alfredo Juan Mayordomo
• Noronha (1918–2003), Brazilian footballer born as Alfredo Eduardo Barreto de Freitas Noronha

Others

• Alfredo Alonso, Cuban-born media executive with Clear Channel Radio
• Alfredo Azancot (1872–?), Chilean-based Portuguese architect
• Alfredo Bonanno (born 1937), Italian conspiracy theorist
• Alfredo Cantu Gonzalez (1946–1968), American United States Marine Corps sergeant
• Alfredo Gonzalez (disambiguation), several people
• Alfredo Gutiérrez (disambiguation), several people
• Alfredo Hernández (disambiguation), several people
• Alfredo Jahn (1867–1940), Venezuelan civil engineer, botanist and geographer
• Alfredo Olivera (1908–?), Uruguayan chess player
• Alfredo Ottaviani (1890–1979), Italian cardinal of the Catholic Church
• Alfredo Pacini (1888–1967), Italian Cardinal of the Roman Catholic Church

• Alfredo Pascual (born 1948), Filipino businessman and former president of the University of the Philippines
• Alfredo Prieto (1965–2015), Salvadoran-American serial killer
• Alfredo Sánchez (disambiguation)
• Alfredo Torero (1930–2004), Peruvian anthropologist
• Alfredo Toro Hardy (born 1950), Venezuelan author, diplomat and public intellectual
• Alfredo Valente (1899–1973), Italian-American photographer
• Arkangel de la Muerte (1966–2018), Mexican luchador and wrestler born as Alfredo Pasillas